Biosketch

NameManuel Fernando Casanova
BirthdateJuly 20, 1953
BirthplaceHato Rey, Puerto Rico
CitizenshipUnited States
Title Kolb endowed chair & Vice-chair for research
Affiliation Department of Psychiatry and Behavioral Sciences, University of Louisville
Address 500 S Preston Street, Bldg 55A, Rm 217, Louisville, KY 40292
Tel+1 502 852 4077
FAX+1 502 813 6665
E-mailm zero casa zero two at louisville dot edu

Education

Institution and location Degree Year(s) Field of study
Universidad de Puerto Rico, Río Piedras B.Sc. 1970–1973 Chemistry
Decanato de Estudios Graduados e Investigación, Universidad de Puerto Rico, Río Piedras 1973–1975 Chemistry
Escuela de Medicina, Universidad de Puerto Rico, San Juan M.D. 1975–1979 Medicine
University District Hospital, San Juan Internship 1979–1980 Medicine
Residency 1980–1983 Neurology

Positions

Institution and locationYear(s)Position held
University District Hospital, Puerto Rico 1982–1983 Chief Resident in Neurology
Neuropathology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland 1983–1984 Clinical Fellow
1984–1986 Research Fellow
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 1984–1986 Clinical Fellow
North Charles Hospital, Baltimore, Maryland 1985 Consultant Neuropathologist
Sinai Hospital, Baltimore, Maryland 1985 Consultant Neuropathologist
Clinical Brain Disorders Branch, National Institute of Mental Health, Washington, D.C. 1986–1991 Neurologist, Neuropathologist
1987–1991 Director of the Brain Bank Unit
Washington, D.C. 1990–1991 Deputy Medical Examiner
D.C. General Hospital, Washington, D.C. 1990–1991 Neuropathologist
Department of Forensic Science, The Graduate School of Arts and Sciences, The George Washington University, Washington, D.C. 1990–1991 Professorial Lecturer
Yakovlev-Haleem Collection, Armed Forces Institute of Pathology, Washington, D.C. 1989–1994 Scientific Expert, Advisory Panel
Medical College of Georgia, Augusta, Georgia 1991–2003 Professor of Psychiatry and Neurology
1991–2003 Consultant in Pathology
1995–2003 Research Resource Liaison Coordinator, Department of Psychiatry
2002–2003 Professor of Anatomy and Cell Biology
2002–2003 Professor, School of Graduate Studies
VA Hospital, Downtown Division, Augusta, Georgia 1991–1998 Psychiatry Service Staff Physician
Dwight David Eisenhower Army Medical Center, Fort Gordon, Georgia 1992–2003 Consultant in Psychiatry
Eisai Inc. 1998–2000 Consultant
Nycomed Amersham 2000 Consultant
Aventis Pasteur Limited 2003 Consultant
Biomedical and Health Sciences Institute, The University of Georgia 2003 Affiliate Member
Department of Psychiatry, University of Louisville, Kentucky 2003–present Kolb Endowed Chair in Psychiatry
2004–present Associate Chair for Research

Honors

Granting institutionYear(s)Title
University of Puerto Rico 1970–1975 Honor Society
University of Puerto Rico School of Medicine 1979 Academic Acknowledgment Plaque
American Medical Association (Puerto Rico Chapter) 1981 Presidential Award
1982 Mead and Johnson Award
American Medical Association 1982–1985 Physician’s Recognition Award
U.S. Department of Health and Human Services 1984–1986 National Research Service Award, PHS Fellowship 5-T32-NS07179-05-0031
1994–present Stanley Scholar
Medical College of Georgia 1995 Distinguished Faculty Award
National Alliance for Autism Research 1996–2002 Scientific Advisory Board
Autism Tissue Program 1999 Tissue Advisory Board (Founding Member)
11th Biennial Winter Workshop on Schizophrenia, Davos, Switzerland 2002 Senior Scientist Award
Medical College of Georgia 2003 Distinguished Clinical Research Award
National Institutes of Health 2005–2009 Developmental Brain Disorders Study Section, Center for Scientific Review
Society for Neurosciences 2007 President, Louisville chapter
Families for Effective Autism Treatment 2011 Contributing Piece award

Publications

Journal articles

Manuel F. Casanova, Luis P. Sánchez-Longo, Jesús Vélez-Borrás. Brainstem encephalitis: a case report of our first experience. Puerto Rico health sciences journal 1982; 1, 127–129.

Manuel F. Casanova, Jesús Vélez-Borrás, Llado I, Rodriguez RJ. Sleep apnea: a diagnosis by itself? Clini-pearls 1982; 5, 4–5.

Manuel F. Casanova, Melendez R. A painful anesthesia. Clini-pearls 1982; 5, 4–5.

Manuel F. Casanova. CT scan diagnosis of parenchymatous cerebral metastases. Boletin de la Asociación Médica de Puerto Rico 1982; 74(2), 13–15.

M. F. Casanova, R. Sánchez, R. Marco. Ciguatera poisoning. Archives of neurology 1982 June; 39(6), 387.

J. Acevedo, M. F. Casanova, A. C. Antonini, H. Morales. Acute polyneuritis associated with dengue. The lancet 1982; 319(8285), 1357.

Manuel F. Casanova. Thinning of digits. Clini-pearls 1983; 6, 2–3.

José Ramírez-Rivera, Manuel F. Casanova, Basil Vassos. Rectifying demodulating phonopneumography: a non-invasive technique for the study of airways obstruction. Puerto Rico health sciences journal 1984; 3, 65–70.

Basil Vassos, Lopez E, Manuel F. Casanova. Demodulating phonopneumograph. Science: ciencia 1984; 11, 26–28.

M. F. Casanova. Vasogenic edema with intraparenchymatous expanding mass lesions: a theory on its pathophysiology and mode of action of hyperventilation and corticosteroids. Medical hypotheses 1984; 13(4), 439–450.

Manuel F. Casanova. Coma: pathophysiology and procedure guide. Boletin de la Asociación Médica de Puerto Rico 1984; 76(12), 524–528.

Manuel F. Casanova, Lary C. Walker, Peter J. Whitehouse, Donald L. Price. Abnormalities of the nucleus basalis in Down’s syndrome. Annals of neurology 1985; 18(3), 310–313.

Manuel F. Casanova, Basil Vassos, Edwin Mejías. A new non-invasive method for the diagnosis of large-joint arthritis: rectifying-demodulating phonopneumography. Boletin de la Asociación Médica de Puerto Rico 1986; 78(1), 9–11.

Linda C. Cork, Nancy H. Sternberger, Ludwig A. Sternberger, Manuel F. Casanova, Robert G. Struble, Donald L. Price. Phosphorylated neurofilament antigens in neurofibrillary tangles in Alzheimer’s disease. Journal of neuropathology and experimental neurology 1986; 45(1), 56–64.

Manuel F. Casanova, Juan C. Troncoso, Donald L. Price. Hematogenous origin of brain macrophages: a case report. Neurology 1986; 36(6), 844–847.

Donald L. Price, Richard J. Altschuler, Robert G. Struble, Manuel F. Casanova, Linda C. Cork, Douglas B. Murphy. Sequestration of tubulin in neurons in Alzheimer’s disease. Brain research 1986; 385(2), 305–310.

Manuel F. Casanova, Juan C. Troncoso, Donald L. Price. Cerebral hemorrhagic infarcts: an autopsy study of 76 cases. Boletin de la Asociación Médica de Puerto Rico 1987; 79(1), 7–11.

Richard M. Zweig, Peter J. Whitehouse, Manuel F. Casanova, Lary C. Walker, William R. Jankel, Donald L. Price. Loss of pedunculopontine neurons in progressive supranuclear palsy. Annals of neurology 1987; 22(1), 18–25.

Pedro R. Lowenstein, Paul A. Slesinger, Harvey S. Singer, Lary C. Walker, Manuel F. Casanova, Donald L. Price, Joseph T. Coyle. An autoradiographic study of the development of [3H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system. Brain research 1987; 431(2), 291–297.

Manuel F. Casanova, Janice R. Stevens, Llewellyn B. Bigelow. Gliosis in schizophrenia. Biological psychiatry 1987; 22(9), 1172–1173.

Robert G. Struble, Richard E. Powers, Manuel F. Casanova, Cheryl A. Kitt, Eleanor C. Brown, Donald L. Price. Neuropeptidergic systems in plaques of Alzheimer’s disease. Journal of neuropathology and experimental neurology 1987; 46(5), 567–584.

Joel E. Kleinman, Manuel F. Casanova, George E. Jaskiw. The neuropathology of schizophrenia. Schizophrenia bulletin 1988; 14(2), 209–216.

Henry N. Wagner Jr., Daniel R. Weinberger, Joel E. Kleinman, Manuel F. Casanova, Clarence J. Gibbs Jr., Raquel E. Gur, Oleh Hornykiewicz, Michael J. Kuhar, Jay W. Pettegrew, Philip Seeman. Neuroimaging and neuropathology. Schizophrenia bulletin 1988; 14(3), 383–397.

Manuel F. Casanova. Brain death: a personal perspective. Boletin de la Asociación Médica de Puerto Rico 1988; 80(5), 173–176.

R. E. Powers, R. G. Struble, M. F. Casanova, D. T. O’Connor, C. A. Kitt, D. L. Price. Innervation of human hippocampus by noradrenergic systems: normal anatomy and structural abnormalities in aging and in Alzheimer’s disease. Neuroscience 1988; 25(2), 401–417.

Richard M. Zweig, John C. Hedreen, William R. Jankel, Manuel F. Casanova, Peter J. Whitehouse, Donald L. Price. Pathology in brainstem regions of individuals with primary dystonia. Neurology 1988; 38(5), 702–706.

Janice R. Stevens, Manuel F. Casanova. Is there a neuropathology of schizophrenia? Biological psychiatry 1988; 24(2), 123–128.

Paul A. Slesinger, Pedro R. Lowenstein, Harvey S. Singer, Lary C. Walker, Manuel F. Casanova, Donald L. Price, Joseph T. Coyle. Development of β1 and β2 adrenergic receptors in baboon brain: an autoradiographic study using [125I]iodocyanopindolol. The journal of comparative neurology 1988; 273(3), 318–329.

Elizabeth A. Majane, Manuel F. Casanova, Hsiu-Ying T. Yang. Biochemical characterization of FMRF-NH2-like peptides in spinal cords of various mammalian species using specific radioimmunoassays. Peptides 1988; 9(5), 1137–1144.

Janice Stevens, Manuel Casanova, Llewellyn Bigelow. Gliosis in schizophrenia. Biological psychiatry 1988; 24(6), 727–729.

Manuel F. Casanova, Robert G. Struble, Peter J. Whitehouse, Donald L. Price. A historical perspective on the neuropathology of dementia with emphasis on the senile plaque. Boletin de la Asociación Médica de Puerto Rico 1988; 80(11), 424–428.

M. Flint Beal, Lary C. Walker, Kenton J. Swartz, Manuel F. Casanova, Donald L. Price. Developmental changes of neuropeptides and amino acids in baboon cortex. Brain research: developmental brain research 1988; 44(1), 156–159.

Maciej Poltorak, Janice R. Stevens, William J. Freed, Manuel F. Casanova. The expression of phosphorylated neurofilament epitopes in human brains. Brain research 1988; 475(2), 328–332.

Richard L. Suddath, Manuel F. Casanova, Terry E. Goldberg, David G. Daniel, John R. Kelsoe Jr., Daniel Roy Weinberger. Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. American journal of psychiatry 1989; 146(4), 464–472.

Manuel F. Casanova, David G. Daniel, Terry E. Goldberg, Richard L. Suddath, Daniel Roy Weinberger. Shape analysis of the middle cranial fossa of schizophrenic patients: a computerized tomographic study. Schizophrenia research 1989; 2(4–5), 333–338.

Manuel F. Casanova, Vassilis Koliatsos, Cynthia A. Jengeleski. A method for the relative quantification of lipofuscin based on a computer image analysis system. Journal of neuroscience methods 1989; 30(1), 11–15.

P. R. Lowenstein, P. A. Slesinger, H. S. Singer, L. C. Walker, M. F. Casanova, L. S. Raskin, D. L. Price, J. T. Coyle. Compartment-specific changes in the density of choline and dopamine uptake sites and muscarinic and dopaminergic receptors during the development of the baboon striatum: a quantitative receptor autoradiographic study. The journal of comparative neurology 1989; 288(3), 428–446.

William G. Honer, Charles A. Kaufmann, Joel E. Kleinman, Manuel F. Casanova, Peter Davies. Monoclonal antibodies to study the brain in schizophrenia. Brain research 1989; 500(1–2), 379–383.

Manuel F. Casanova, Mark Zito, Llewellyn B. Bigelow, Bryan D. Berthot, Richard D. Sanders, Joel E. Kleinman. Axonal counts of the corpus callosum of schizophrenic patients. The journal of neuropsychiatry and clinical neurosciences 1989; 1(4), 391–393.

George W. Christison, Manuel F. Casanova, Daniel R. Weinberger, Robert Rawlings, Joel E. Kleinman. A quantitative investigation of hippocampal pyramidal cell size, shape, and variability of orientation in schizophrenia. Archives of general psychiatry 1989 Nov; 46(11), 1027–1032.

Manuel F. Casanova. Xanthoma of the choroid plexus: a case report during gestation. Boletin de la Asociación Médica de Puerto Rico 1989; 81(12), 475–476.

SakkuBai Naidu, Susan Hyman, Piazza K, Savedra J, Perman J, Gary Wenk, Cheryl Kitt, Juan Troncoso, Donald Price, Manuel Casanova, Miller D, George Thomas, Ernst Niedermeyer, Hugo Moser. The Rett syndrome: progress report on studies at the Kennedy Institute. Brain & development 1990; 12(1), 5–7.

Manuel F. Casanova, Channavajjala M. Prasad, Ivan Waldman, Barbara Illowsky Karp, Bradley Stein, Danniel R. Weinberger, Joel B. Kleinman. No difference in basal ganglia mineralization between schizophrenic and nonschizophrenic patients: a quantitative computerized tomographic study. Biological psychiatry 1990; 27(2), 138–142.

Manuel F. Casanova, Ivan N. Waldman, Joel E. Kleinman. A postmortem quantitative study of iron in the globus pallidus of schizophrenic patients. Biological psychiatry 1990; 27(2), 143–149.

Manuel F. Casanova, Joel E. Kleinman. The neuropathology of schizophrenia: a critical assessment of research methodologies. Biological psychiatry 1990; 27(3), 353–362.

Manuel F. Casanova, Mark Zito, Terry Goldberg, Anissa Abi-Dargham, Richard Sanders, Llewellyn B. Bigelow, E. Fuller Torrey and Daniel R. Weinberger. Shape distortion of the corpus callosum of monozygotic twins discordant for schizophrenia. Schizophrenia research 1990 Mar; 3(2), 155–156.

Maciej Poltorak, William J. Freed, Manuel F. Casanova. Prenatal exposure to ethanol causes a delay in the developmental expression of neurofilament epitopes in cerebellum. Pharmacology, biochemistry, and behavior 1990; 35(3), 693–698.

RL Suddath, GW Christison, EF Torrey, MF Casanova, DR Weinberger. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. The New England journal of medicine 1990 Mar 22; 322(12), 789–794.

Manuel F Casanova, Richard D Sanders, Terry E Goldberg, Llewellyn B Bigelow, George Christison, E Fuller Torrey, Daniel R Weinberger. Morphometry of the corpus callosum in monozygotic twins discordant for schizophrenia: a magnetic resonance imaging study. Journal of neurology, neurosurgery, and psychiatry 1990 May; 53(5), 416–421. PMCID: PMC488059

Manuel F. Casanova, Mark Zito, Terry E. Goldberg, E. Fuller Torrey, Lewellyn B. Bigelow, Richard D. Sanders, Daniel R. Weinberger. Corpus callosum curvature in schizophrenic twins. Biological psychiatry 1990; 28(1), 83–84.

Manuel F. Casanova, Nicholas W. Carosella, Joel E. Kleinman. Neuropathological findings in a suspected case of childhood schizophrenia. The journal of neuropsychiatry and clinical neurosciences 1990; 2(3), 313–319.

Lori L. Altshuler, Manuel F. Casanova, Terry E. Goldberg, Joel E. Kleinman. The hippocampus and parahippocampus in schizophrenia, suicide, and control brains. Archives of general psychiatry 1990; 47(11), 1029–1034.

Manuel F. Casanova, Terry E. Goldberg, Richard L. Suddath, David G. Daniel, Robert Rawlings, Donald G. Lloyd, Harry L. Loats, Joel E. Kleinman, Daniel R. Weinberger. Quantitative shape analysis of the temporal and prefrontal lobes in schizophrenic patients: a magnetic resonance image study. The journal of neuropsychiatry and clinical neurosciences 1990; 2(4), 363–372.

Manuel F. Casanova, Janice R. Stevens, Joel E. Kleinman. Astrocytosis in the molecular layer of the dentate gyrus: a study in Alzheimer’s disease and schizophrenia. Psychiatry research 1990; 35(2), 149–166.

Thomas M. Hyde, Manuel F. Casanova, Joel E. Kleinman, Daniel R. Weinberger. Neuroanatomical and neurochemical pathology in schizophrenia. Review of psychiatry 1991 May; 10, 7–23.

Daniel R. Weinberger, Richard L. Suddath, Manuel F. Casanova, E. Fuller Torrey, Joel E. Kleinman. Crow’s “lateralization hypothesis” for schizophrenia. Archives of general psychiatry 1991 January; 48(1), 85–87.

Arthur D. Weissman, Manuel F. Casanova, Joel E. Kleinman, Edythe D. London, Errol B. De Souza. Selective loss of cerebral cortical sigma, but not PCP binding sites in schizophrenia. Biological psychiatry 1991; 29(1), 41–54.

Manuel F. Casanova, SakkuBai Naidu, Terry E. Goldberg, Hugo W. Moser, Suzan Khoromi, A. Kumar, Joel E. Kleinman, Daniel R. Weinberger. Quantitative magnetic resonance imaging in Rett syndrome. The journal of neuropsychiatry and clinical neurosciences 1991; 3(1), 66–72.

Arthur D. Weissman, Manuel F. Casanova, Joel E. Kleinman, Errol B. De Souza. PCP and sigma receptors in brain are not altered after repeated exposure to PCP in humans. Neuropsychopharmacology 1991; 4(2), 95–102.

David G. Daniel, Emiliy Kim, Debra Kostianovsky, Terry E. Goldberg, Manuel F. Casanova, David Pickar, Joel E. Kleinman, Daniel Roy Weinberger. Computed tomography measurements of brain density in schizophrenia. Biological psychiatry 1991; 29(8), 745–756.

Ana Hitri, Diane Venable, Hung Q. Nguyen, Manuel F. Casanova, Joel E. Kleinman, Richard J. Wyatt. Characteristics of [3H]GBR 12935 binding in the human and rat frontal cortex. Journal of neurochemistry 1991; 56(5), 1663–1672.

Han-Tong Chen, Manuel F. Casanova, Joel E. Kleinman, Mark Zito, David Goldman, Markku Linnoila. 3H-paroxetine binding in brains of alcoholics. Psychiatry research 1991; 38(3), 293–299.

Este Armstrong, Maria Curtis, Daniel P. Buxhoeveden, Carolyn Fregoe, Karl Zilles, Manuel F. Casanova, William F. McCarthy. Cortical gyrification in the rhesus monkey: a test of the mechanical folding hypothesis. Cerebral cortex 1991; 1(5), 426–432.

Manuel F. Casanova. Astrocytosis and schizophrenia. Schizophrenia research 1991; 5(3), 186–187.

Marc Laruelle, Anita Sidhu, Manuel F. Casanova, Daniel R. Weinberger, Joel E. Kleinman. Characterization of [125I]SCH 23982 binding in human brain: comparison with [3H]SCH 23390. Neuroscience letters 1991; 131(2), 273–276.

Gary L. Wenk, SakkuBai Naidu, Manuel F. Casanova, Cheryl A. Kitt, Hugo W. Moser. Altered neurochemical markers in Rett’s syndrome. Neurology 1991; 41(11), 1753–1756.

Manuel F. Casanova, Silvia O. Comparini, Kim RW, Joel E. Kleinman. Staining intensity of brain iron in patients with schizophrenia: a postmortem study. The journal of neuropsychiatry and clinical neurosciences 1992; 4(1), 36–41.

R. C. Alexander, S. A. Spector, M. Casanova, J. Kleinman, R. J. Wyatt, D. G. Kirch. Search for cytomegalovirus in the postmortem brains of schizophrenic patients using the polymerase chain reaction. Archives of general psychiatry 1992; 49(1), 47–53.

Jeffrey N. Joyce, Nedra Lexow, Soo Jin Kim, Roman Artymyshyn, Shari Senzon, David Lawerence, Manuel F. Cassanova, Joel E. Kleinman, Edward D. Bird, Andrew Winokur. Distribution of beta-adrenergic receptor subtypes in human post-mortem brain: alterations in limbic regions of schizophrenics. Synapse 1992; 10(3), 228–246.

M. Laruelle, G. E. Jaskiw, B. K. Lipska, B. Kolachana, M. F. Casanova, J. E. Kleinman, D. R. Weinberger. D1 and D2 receptor modulation in rat striatum and nucleus accumbens after subchronic and chronic haloperidol treatment. Brain research 1992; 575(1), 47–56.

Janice R. Stevens, Manuel F. Casanova, Maciej Poltorak, Germain L, Buchan GC. Comparison of immunocytochemical and Holzer’s methods for detection of acute and chronic gliosis in human postmortem material. The journal of neuropsychiatry and clinical neurosciences 1992; 4(2), 168–173.

Manuel F. Casanova. The Concept of Schizophrenia: Historical Perspectives—edited by John G. Howells, M.D.; Washington, D.C., American Psychiatric Press, 1991, 211 pages, $30. Hospital & community psychiatry 1992; 43(8), 848–849.

Linton Stephen Holsenbeck III, Laura Marie Davidson, Robin Elno Hostetter, Manuel Fernando Casanova, David Oliver Taylor, Colin Thomas Kelley, Charles Perrotta Jr., Richard Lewis Borison, Bruce Diamond. Ventricle-to-brain ratio and symptoms at the onset of first-break schizophrenia. Schizophrenia bulletin 1992; 18(3), 427–435.

Manuel F. Casanova, Mark Zito, Lori Altshuler, Daniel R. Weinberger, Joel E. Kleinman. Normal nucleolar size of entorhinal cortex cells in schizophrenia. Psychiatry research 1992; 44(1), 79–82.

R. C. Alexander, G. Cabirac, T. Lowenkopf, M. Casanova, J. Kleinman, R. J. Wyatt, D. Kirch. Search for evidence of herpes simplex virus, type 1, or varicella-zoster virus infection in postmortem brain tissue from schizophrenic patients. Acta psychiatrica Scandinavica 1992 November; 86(5), 418–420.

Craig N. Karson, Manuel F. Casanova, Joel E. Kleinman, W. S. T. Griffin. Choline acetyltransferase in schizophrenia. American journal of psychiatry 1993; 150(3), 454–459.

Jeffrey N. Joyce, A. Shane, Nedra Lexow, Andrew Winokur, Manuel F. Casanova, Joel E. Kleinman. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 1993; 8(4), 315–336.

Manuel F. Casanova, Nicholas W. Carosella, James M. Gold, Joel E. Kleinman, Daniel R. Weinberger, Richard E. Powers. A topographical study of senile plaques and neurofibrillary tangles in the hippocampi of patients with Alzheimer’s disease and cognitively impaired patients with schizophrenia. Psychiatry research 1993; 49(1), 41–62.

Marc Laruelle, Anissa Abi-Dargham, Manuel F. Casanova, Rosanne Toti Daniel R. Weinberger, Joel E. Kleinman. Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: a postmortem study. Archives of general psychiatry 1993; 50(10), 810–818.

Kathleen A. Crapanzano, Manuel F. Casanova, Victor E. Toro, Brian Gallagher. Drinking behavior as a result of a right hippocampal ictal focus. Biological psychiatry 1993; 34(12), 889–892.

Ana Hitri, Manuel F. Casanova, Joel E. Kleinman, Richard J. Wyatt. Fewer dopamine transporter receptors in the prefrontal cortex of cocaine users. American journal of psychiatry 1994 Jul; 151(7), 1074–1076.

Nedra Lexow, Jeffery N. Joyce, Soo Jin Kim, Jennifer Phillips, Manuel F. Casanova, Edward D. Bird, Joel E. Kleinman, Andrew Winokur. Alterations in TRH receptors in temporal lobe of schizophrenics: a quantitative autoradiographic study. Synapse 1994; 18(4), 315–327.

Richard G. Petty, Patrick E. Barta, Godfrey D. Pearlson, Iain K. McGilchrist, Robert W. Lewis, Allen Y. Tien, Ann E. Pulver, D. Darrell Vaughn, Manuel F. Casanova, Richard E. Powers. Reversal of asymmetry of the planum temporale in schizophrenia. American journal of psychiatry 1995; 152(5), 715–721.

Manuel F. Casanova, Kathleen A. Crapanzano, Glenn Mannheim, Markus Kruesi. Sydenham’s chorea and schizophrenia: a case report. Schizophrenia research 1995 Jul; 16(1), 73–76.

Richard Jed Wyatt, Farouk Karoum, Manuel F. Casanova. Decreased DOPAC in the anterior cingulate cortex of individuals with schizophrenia. Biological psychiatry 1995 Jul 1; 38(1), 4–12.

Manuel F. Casanova. Elmer Ernest Southard 1876-1920. Biological psychiatry 1995 Jul 15; 38(2), 71–73.

Gad M. Gilad, Varda H. Gilad, Manuel F. Casanova, Robert A. Casero Jr. Polyamines and their metabolizing enzymes in human frontal cortex and hippocampus: preliminary measurements in affective disorders. Biological psychiatry 1995 Aug 15; 38(4), 227–234.

Patrick E. Barta, Richard G. Petty, Iain K. McGilchrist, Robert W. Lewis, Matthew Jerram, Manuel F. Casanova, Richard E. Powers, Louis B. Brill II, Godfrey D. Pearlson. Asymmetry of the planum temporale: methodological considerations and clinical associations. Psychiatry research 1995; 61(3), 137–150.

Manuel F. Casanova, Markus Kruesi, Glenn Mannheim. Multiple sclerosis and bipolar disorder: a case report with autopsy findings. The journal of neuropsychiatry and clinical neurosciences 1996; 8(2), 206–208.

Manuel F. Casanova. Wernicke’s disease and schizophrenia: a case report and review of the literature. International journal of psychiatry in medicine 1996; 26(3), 319–328.

Judith M. Rumsey, Manuel Casanova, Glenn B. Mannheim, Nicholas Patronas, Nathan DeVaughn, Susan D. Hamburger, Tracy Aquino. Corpus callosum morphology, as measured with MRI, in dyslexic men. Biological psychiatry 1996 May 1; 39(9), 769–775.

Natalya A. Uranova, Manuel F. Casanova, Nathan M. DeVaughn, Diana D. Orlovskaya, Dmitry V. Denisov. Ultrastructural alterations of synaptic contacts and astrocytes in postmortem caudate nucleus of schizophrenic patients. Schizophrenia research 1996 Oct 18; 22(1), 81–83.

Manuel F. Casanova. The temporolimbic system theory of paranoid schizophrenia. Schizophrenia bulletin 1997; 23(3), 513–515.

Manuel F. Casanova. Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophrenia bulletin 1997; 23(3), 517–519.

Patrick E. Barta, Godfrey D. Pearlson, Louis B. Brill II, Richard Royall, Iain K. McGilchrist, Ann E. Pulver, Richard E. Powers, Manuel F. Casanova, Allen Y. Tien, Sophia Frangou, Richard G. Petty. Planum temporale asymmetry reversal in schizophrenia: replication and relationship to gray matter abnormalities. American journal of psychiatry 1997; 154(5), 661–667.

William H. Hoffman, Manuel F. Casanova, Jose A. Bauza, Gregory G. Passmore, Elizabeth A. Sekul. Computer analysis of magnetic resonance imaging of the brain in children and adolescents after treatment of diabetic ketoacidosis. Journal of diabetes and its complications 1999; 13(4), 176–181.

Daniel Buxhoeveden, Emil Roy, Andrew Switala, Manuel F. Casanova. Reduced interneuronal space in schizophrenia. Biological psychiatry 2000; 47(7), 681–683.

Daniel P. Buxhoeveden, Andrew E. Switala, Emil Roy, Manuel F. Casanova. Quantitative analysis of cell columns in the cerebral cortex. Journal of neuroscience methods 2000; 97(1), 7–17.

Daniel Buxhoeveden, Manuel Casanova. Comparative lateralisation patterns in the language area of human, chimpanzee, and rhesus monkey brains. Laterality 2000; 5(4), 315–330.

Manuel F. Casanova, Diane S. Solursh, Lionel Paul Solursh, Emil Roy, Lance Thigpen. The history of child pornography on the Internet. Journal of sex education and therapy 2001; 25(4), 245–251.

Daniel P. Buxhoeveden, Andrew E. Switala, Mark Litaker, Emil Roy, Manuel F. Casanova. Lateralization of minicolumns in human planum temporale is absent in nonhuman primate cortex. Brain, behavior and evolution 2001; 57(6), 349–358.

Daniel P. Buxhoeveden, Andrew E. Switala, Emil Roy, Mark Litaker, Manuel F. Casanova. Morphological differences between minicolumns in human and nonhuman primate cortex. American journal of physical anthropology 2001; 115(4), 361–371.

Manuel F. Casanova, William D. Hill, Benam Pourdihimi. Senile plaques exert no mass lesion effect on surrounding neurons. Journal of neuroscience methods 2001; 110(1–2), 125–133.

D. Buxhoeveden, A. Fobbs, E. Roy, M. Casanova. Quantitative comparison of radial cell columns in children with Down’s syndrome and controls. Journal of intellectual disability research 2002; 46(1), 76–81.

Manuel F. Casanova, Daniel P. Buxhoeveden, Andrew E. Switala, Emil Roy. Asperger’s syndrome and cortical neuropathology. Journal of child neurology 2002 February; 17(2), 142–145.

Manuel F. Casanova, Daniel P. Buxhoeveden, Andrew E. Switala, Emil Roy. Minicolumnar pathology in autism. Neurology 2002 February 12; 58(3), 428–432.

Manuel F. Casanova, Janice R. Stevens, Rosemary Brown, Claire Royston, Clive Bruton. Disentangling the pathology of schizophrenia and paraphrenia. Acta neuropathologica 2002; 103(4), 313–320.

Daniel P. Buxhoeveden, Manuel F. Casanova. The minicolumn hypothesis in neuroscience. Brain 2002; 125(5), 935–951.

Manuel F. Casanova, Brian Rothberg. Shape distortion of the hippocampus: a possible explanation for the reported pyramidal cell disarray in schizophrenia. Schizophrenia research 2002; 55(1–2), 19–24.

Manuel F. Casanova, Daniel P. Buxhoeveden, Morris Cohen, Andrew E. Switala, Emil L. Roy. Minicolumnar pathology in dyslexia. Annals of neurology 2002; 52(1), 108–110.

Manuel F. Casanova, Daniel P. Buxhoeveden, Andrew E. Switala, Emil Roy. Neuronal density and architecture (gray level index) in the brains of autistic patients. Journal of child neurology 2002; 17(7), 515–521.

Manuel F. Casanova, Glenn Mannheim, Markus Kruesi. Hippocampal pathology in two mentally ill paraphiliacs. Psychiatry research: neuroimaging 2002; 115(1–2), 79–89.

Daniel P. Buxhoeveden, Manuel F. Casanova. The minicolumn and evolution of the brain. Brain, behavior and evolution 2002; 60(3), 125–151.

Manuel F. Casanova, Daniel P. Buxhoeveden, Caroline Brown. Clinical and macroscopic correlates of minicolumnar pathology in autism. Journal of child neurology 2002; 17(9), 692–695.

Manuel F. Casanova. Modular concepts of brain organization and the neuropathology of psychiatric conditions. Psychiatry research 2003; 118(1), 101–102.

Manuel F. Casanova, Daniel P. Buxhoeveden, Andrew Edward Switala, Emil Roy. Rett syndrome as a minicolumnopathy. Clinical neuropathology 2003; 22(4), 163–168.

Manuel F. Casanova. Preservation of hippocampal pyramidal cells in paraphrenia. Schizophrenia research 2003; 62(1–2), 141–146.

Manuel F. Casanova, Eric C. Lindzen. Changes in gray-/white-matter ratios in the parahippocampal gyri of late-onset schizophrenia patients. American journal of geriatric psychiatry 2003; 11(6), 605–609.

Manuel F. Casanova, Julio M. Araque. Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging. Psychiatry research 2003; 121(1), 59–87.

Manuel F. Casanova, Daniel Buxhoeveden, Juan Gomez. Disruption in the inhibitory architecture of the cell minicolumn: implications for autism. The neuroscientist 2003; 9(6), 496–507.

Emil Roy, Manuel F. Casanova, Vandna Jerath. Autistic poetry as therapy. Journal of poetry therapy 2004; 17(1), 33–38.

Manuel F. Casanova, Julio Araque, Jay Giedd, Judith M. Rumsey. Reduced brain size and gyrification in the brains of dyslexic patients. Journal of child neurology 2004; 19(4), 275–281.

Manuel F. Casanova. Intracortical circuitry: one of psychiatry’s missing assumptions. European archives of psychiatry and clinical neuroscience 2004; 254(3), 148–151.

Manuel F. Casanova. White matter volume increase and minicolumns in autism. Annals of neurology 2004; 56(3), 453.

Daniel Buxhoeveden, Manuel F. Casanova. Accelerated maturation in brains of patients with Down syndrome. Journal of intellectual disability research 2004; 48(7), 704–705.

Markus J.P. Kruesi, Manuel F. Casanova, Glenn Mannheim, Adrienne Johnson-Bilder. Reduced temporal lobe volume in early onset conduct disorder. Psychiatry research: neuroimaging 2004; 132(1), 1–11.

Manuel F. Casanova, Leonie de Zeeuw, Andrew Switala, Pawel Kreczmanski, Hubert Korr, Norbert Ulfig, Helmut Heinsen, Harry W.M. Steinbusch, Christoph Schmitz. Mean cell spacing abnormalities in the neocortex of patients with schizophrenia. Psychiatry research 2005; 133(1), 1–12.

Manuel F. Casanova, James D. Christensen, Jay Giedd, Judith M. Rumsey, David L. Garver, Gregory C. Postel. Magnetic resonance imaging study of brain asymmetries in dyslexic patients. Journal of child neurology 2005; 20(10), 842–847.

Ratnam S. Seelan, Anthony J. Janckila, Ranga N. Parthasarathy, Manuel F. Casanova. The importance of using equimolar DNA for transfection analysis of the 5′ flanking promoter regions of genes. Analytical biochemistry 2006; 349(2), 306–308.

M. J. P. Kruesi, M. F. Casanova. White matter in liars. The British journal of psychiatry 2006; 188(3), 293–294.

Steven A. Chance, Manuel F. Casanova, Andy E. Switala, Timothy J. Crow, Margaret M. Esiri. Minicolumn thinning in temporal lobe association cortex but not primary auditory cortex in normal human ageing. Acta neuropathologica 2006; 111(5), 459–464.

Manuel F. Casanova, Juan Trippe II. Regulatory mechanisms of cortical laminar development. Brain research: brain research reviews 2006 Jun; 51(1), 72–84.

Manuel F. Casanova, Imke A.J. van Kooten, Andrew E. Switala, Herman van Engeland, Helmut Heinsen, Harry W.M. Steinbusch, Patrick R. Hof, Juan Trippe, Janet Stone, Christoph Schmitz. Minicolumnar abnormalities in autism. Acta neuropathologica 2006 Sep; 112(3), 287–303.

Manuel F. Casanova. Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy. The neuroscientist 2006 Oct 1; 12(5), 435–441.

M.F. Casanova, I. van Kooten, A.E. Switala, H. van Engeland, H. Heinsen, H.W.M. Steinbusch, P.R. Hof, C. Schmitz. Abnormalities of cortical minicolumnar organization in the prefrontal lobes of autistic patients. Clinical neuroscience research 2006 Oct; 6(3–4), 127–133.

S.A. Chance, M.F. Casanova, A.E. Switala, T.J. Crow. Minicolumnar structure in Heschl’s gyrus and planum temporale: asymmetries in relation to sex and callosal fiber number. Neuroscience 2006 Dec 28; 143(4), 1041–1050.

Manuel F. Casanova, Juan Trippe II, Andrew Switala. A temporal continuity to the vertical organization of the human neocortex. Cerebral cortex 2007 Jan; 17(1), 130–137.

Manuel F. Casanova, Andrew E. Switala, Juan Trippe. A comparison study of the vertical bias of pyramidal cells in the hippocampus and neocortex. Developmental neuroscience 2007 Jan; 29(1–2), 193–200.

Manuel F. Casanova, Aly Farag, Ayman El-Baz, Meghan Mott, Hossam Hassan, Rachid Fahmi, Andrew E. Switala. Abnormalities of the gyral window in autism: a macroscopic correlate to a putative minicolumnopathy. Journal of special education and rehabilitation 2007 Jan; 2006(1–2), 85–101.

Manuel F. Casanova, Jodie Steele. Autism: an overview. Louisville medicine 2007 Apr; 54(11), 503, 505, 531.

Manuel F. Casanova, Meghan Mott. The neuropathology of autism: a selective review. Journal of special education and rehabilitation 2007 Jul; 2006(3–4), 21–35.

William H. Hoffman, Manuel F. Casanova, Cornelia D. Cudricic, Ekaterina Zakranskaia, Roopa Venugopalan, Sukriti Nag, Michael J. Oglesbee, Horea Rus. Neuroinflammatory response of the choroid plexus epithelium in fatal diabetic ketoacidosis. Experimental and molecular pathology 2007 Aug; 83(1), 65–72. PMCID: PMC1950467

Manuel F. Casanova. Schizophrenia seen as a deficit in the modulation of cortical minicolumns by monoaminergic systems. International review of psychiatry 2007 Aug; 19(4), 361–372.

Manuel F. Casanova. The neuropathology of autism. Brain Pathology 2007 October; 17(4), 422–433.

Manuel F. Casanova, Andrew E. Switala, Juan Trippe, Michael Fitzgerald. Comparative minicolumnar morphometry of three distinguished scientists. Autism 2007 Nov; 11(6), 557–569.

Manuel F. Casanova. The minicolumnopathy of autism: a link between migraine and gastrointestinal symptoms. Medical hypotheses 2008 Jan; 70(1), 73–80. PMCID: PMC2211386

Manuel F. Casanova, Christopher R. Tillquist. Encephalization, emergent properties, and psychiatry: a minicolumnar perspective. The Neuroscientist 2008 Feb; 14(1), 101–118.

Ratnam S. Seelan, Abdelnaby Khalyfa, Jaganathan Lakshmanan, Manuel F. Casanova, Ranga N. Parthasarathy. Deciphering the lithium transcriptome: microarray profiling of lithium modulated gene expression in human neuronal cells. Neuroscience 2008 Feb; 151(4), 1184–1197.

Manuel F. Casanova, Anouar I. Konkachbaev, Andrew E. Switala, Adel S. Elmaghraby. Recursive trace line method for detecting myelinated bundles: a comparison study with pyramidal cell arrays. Journal of Neuroscience Methods 2008 Mar; 168(2), 367–372. PMCID: PMC2266875

Manuel F. Casanova, Pawel Kreczmanski, Juan Trippe II, Andrew Switala, Helmut Heinsen, Harry W.M. Steinbusch, Christoph Schmitz. Neuronal distribution in the neocortex of schizophrenic patients. Psychiatry research 2008 Apr 15; 158(3), 267–277.

C. Fajardo, M.I. Escobar, E. Buriticá, G. Arteaga, J. Umbarila, M.F. Casanova, H. Pimienta. Von Economo neurons are present in the dorsolateral (dysgranular) prefrontal cortex of humans. Neuroscience Letters 2008 Apr 25; 435(3), 215–218.

A. El-Baz, M. Casanova, G. Gimel’farb, M. Mott, A. Switala. An MRI-based diagnostic framework for early diagnosis of dyslexia. International Journal of Computer Assisted Radiology and Surgery 2008 Sep; 3(3–4): 181–189.

Steven A. Chance, Manuel F. Casanova, Andy E. Switala, Timothy J. Crow. Auditory cortex asymmetry, altered minicolumn spacing and absence of ageing effects in schizophrenia. Brain 2008 Dec; 131(12): 3178–3192.

Manuel F. Casanova, Juan Trippe II, Christopher Tillquist, Andrew E. Switala. Morphometric variability of minicolumns in the striate cortex of Homo sapiens, Macaca mulatta, and Pan troglodytes. Journal of Anatomy 2009 Feb; 214(2): 226–234.

Estate Sokhadze, Joshua Baruth, Allan Tasman, Lonnie Sears, Grace Mathai, Ayman El-Baz, Manuel F. Casanova. Event-related potential study of novelty processing abnormalities in autism. Applied Psychophysiology and Biofeedback 2009 March; 34(1): 37–51.

Estate M. Sokhadze, Ayman El-Baz, Joshua Baruth, Grace Mathai, Lonnie Sears, Manuel F. Casanova. Effects of low frequency repetitive transcranial magnetic stimulation (rTMS) on gamma frequency oscillations and event-related potentials during processing of illusory figures in autism. Journal of Autism and Developmental Disorders 2009 April; 39(4): 619–634.

Ratnam S. Seelan, Jaganathan Lakshmanan, Manuel F. Casanova, Ranga N. Parthasarathy. Identification of myo-inositol-3-phosphate synthase isoforms: characterization, expression and putative role of a 16 kDa γc isoform. Journal of Biological Chemistry 2009 Apr 3; 284(14): 9443–9457.

Manuel Casanova, Juan Trippe. Radial cytoarchitecture and patterns of cortical connectivity in autism. Philosophical Transactions of the Royal Society, B. Biological Sciences 2009 May 27; 364(1522): 1433–1436.

Manuel F. Casanova, Ayman El-Baz, Meghan Mott, Glenn Mannheim, Hossam Hassan, Rachid Fahmi, Jay Giedd, Judith M. Rumsey, Andrew E. Switala, Aly Farag. Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy. Journal of Autism and Developmental Disorders 2009 May; 39(5): 751–764.

Manuel F. Casanova. La esquizofrenia como condición neurológica debido a una falta en la lateralización del cerebro: observaciones micro- y macroscópicas. Revista de Neurología 2009 Aug 1; 49(3): 136–142.

Estate (Tato) Sokhadze, Joshua Baruth, Manuel Casanova. Neuropathological theories and EEG gamma oscillation abnormalities in autism. NeuroConnections 2009 Aug 11; 2009(Fall): 34–37.

Manuel F. Casanova, Ayman S. El-Baz, Eric Vanbogaert, Praveen Narahari, Juan Trippe. Minicolumnar width: comparison between supragranular and infragranular layers. Journal of Neuroscience Methods 2009 Oct 30; 184(1): 19–24.

Emily L. Williams, Manuel F. Casanova. Autism and dyslexia: a spectrum of cognitive styles as defined by minicolumnar morphometry. Medical hypotheses 2010 Jan; 74(1):59–62.

Manuel F. Casanova, Ayman S. El-Baz, Jay Giedd, Judith M. Rumsey, Andrew E. Switala. Increased white matter gyral depth in dyslexia: implications for corticocortical connectivity. Journal of Autism and Developmental Disorders 2010 January; 40(1): 21–29.

Manuel F. Casanova, Juan Trippe II, Christopher R. Tillquist, Andrew E. Switala. Radial structure of dolphin insula: dolphin insula reflects minicolumnar organization of mammalian isocortex. Translational Neuroscience 2010 March; 1(1): 37–42.

Manuel F. Casanova. Cortical organization: anatomical findings based on systems theory. Translational Neuroscience 2010 March; 1(1): 62–71.

Manuel F. Casanova, Ayman El-Baz, Eric Vanbogaert, Praveen Narahari, Andrew Switala. A topographic study of minicolumnar core width by lamina comparison between autistic subjects and controls: possible minicolumnar disruption due to an anatomical element in-common to multiple laminae. Brain Pathology 2010 Mar; 20(2): 451–458.

Estate Sokhadze, Joshua Baruth, Ayman El-Baz, Timothy Horrell, Guela Sokhadze, Thomas Carroll, Allan Tasman, Lonnie Sears, Manuel F. Casanova. Impaired error monitoring and correction function in autism. Journal of Neurotherapy 2010 May; 14(2): 79-95.

Manuel F. Casanova. The pathology of paraphrenia. Current Psychiatry Reports 2010 Jun; 12(3): 196–201.

Manuel F. Casanova. The role of the entorhinal cortex in paraphrenia. Current Psychiatry Reports 2010 Jun; 12(3): 202–207.

Estate Sokhadze, Joshua Baruth, Allan Tasman, Mehreen Mansoor, Rajesh Ramaswamy, Lonnie Sears, Grace Mathai, Ayman El-Baz, Manuel F. Casanova. Low-frequency repetitive transcranial magnetic stimulation (rTMS) affects event-related potential measures of novelty processing in autism. Applied Psychophysiology and Biofeedback 2010 Jun; 35(2): 147–161.

Manuel F. Casanova, Ayman El-Baz, Ahmed Elnakib, Jay Giedd, Judith M. Rumsey, Emily L. Williams, Andrew E. Switala. Corpus callosum shape analysis with application to dyslexia. Translational Neuroscience 2010 Jun; 1(2): 124–130.

Joshua M. Baruth, Manuel F. Casanova, Lonnie Sears, Estate Sokhadze. Early-stage visual processing abnormalities in high-functioning autism spectrum disorder (ASD). Translational Neuroscience 2010 Jun; 1(2): 177–187.

E. L. Williams, M. F. Casanova. Potential teratogenic effects of ultrasound on corticogenesis: implications for autism. Medical Hypotheses 2010 Jul; 75(1): 53–58.

Joshua M. Baruth, Manuel F. Casanova, Ayman El-Baz, Tim Horrell, Grace Mathai, Lonnie Sears, Estate Sokhadze. Low-frequency repetitive transcranial magnetic stimulation modulates evoked-gamma frequency oscillations in autism spectrum disorder. Journal of Neurotherapy 2010 July; 14(3): 179–194.

Emily L. Williams, Manuel F. Casanova. Autism or autisms? Finding the lowest common denominator. Boletín de la Asociación Médica de Puerto Rico 2010 October; 102(4): 17–24.

Ratnam S. Seelan, M. Michele Pisano, Robert M. Greene, Manuel F. Casanova, Ranga N. Parthasarathy. Differential methylation of the gene encoding myo-inositol 3-phosphate synthase (Isyna1) in rat tissues. Epigenomics 2011 February; 3(1): 111–124.

Manuel F. Casanova, Ayman El-Baz, Ahmed Elnakib, Andrew E. Switala, Emily L. Williams, Diane L. Williams, Nancy J. Minshew, Thomas E. Conturo. Quantitative analysis of the shape of the corpus callosum in patients with autism and comparison individuals. Autism 2011 March; 15(2): 223–238.

Joshua M. Baruth, Emily L. Williams, Estate Sokhadze, Ayman El-Baz, Manuel F. Casanova. Beneficial effects of repetitive transcranial magnetic stimulation (rTMS) on behavioral outcome measures in autism spectrum disorder. Autism Science Digest 2011 April; 1(1): 52–57.

Emily L. Williams, Manuel F. Casanova. Prenatal ultrasound: it’s not just a photograph. Autism Science Digest 2011 April; 1(1): 58–60.

Emily L. Williams, Manuel F. Casanova. Above genetics: lessons from cerebral development in autism. Translational Neuroscience 2011 June; 2(2): 106–120.

Brynn A. Dombroski, Andrew E. Switala, Ayman S. El-Baz, Manuel F. Casanova. Gyral window mapping of typical cortical folding using MRI. Translational Neuroscience 2011 June; 2(2): 142–147.

Manuel F. Casanova, Sergio E. Starkstein, Kurt A. Jellinger. Clinicopathological correlates of behavioral and psychological symptoms of dementia. Acta Neuropathologica 2011 August; 122(2): 117–135.

Vladimír Blažek, Jaroslav Brůžek, Manuel F. Casanova. Plausible mechanisms for brain structural and size changes in human evolution. Collegium Antropologicum 2011 September; 35(3): 949–955.

Ayman El-Baz, Ahmed Elnakib, Manuel F. Casanova, Georgy Gimel’farb, Andrew E. Switala, Desha Jordan, Sabrina Rainey. Accurate automated detection of autism related corpus callosum abnormalities. Journal of Medical Systems 2011 October; 35(5): 929–939.

Manuel F. Casanova, Ayman El-Baz, Andrew E. Switala. Laws of conservation as related to brain growth, aging, and evolution: symmetry of the minicolumn. Frontiers in Neuroanatomy 2011 December 26, 5: 66.

Estate M. Sokhadze, Joshua M. Baruth, Lonnie Sears, Guela E. Sokhadze, Ayman S. El-Baz, Emily L. Williams, Robert Klapheke, Manuel F. Casanova. Event-related potential study of attention regulation during illusory figure categorization task in ADHD, autism spectrum disorder, and typical children. Journal of Neurotherapy 2012 March, 16(1): 12–31.

Emily L. Williams, Ayman El-Baz, Matthew Nitzken, Andrew E. Switala, Manuel F. Casanova. Spherical harmonic analysis of cortical complexity in autism and dyslexia. Translational Neuroscience 2012 March; 3(1): 36–40.

Мануэль Ф. Касанова, Меган Мотт, Тато М. Сохадзе. Невропатология аутизма: обзор современной литературы. Сибирский вестник специального образования 2012 April; 6(2): pp?.

Estate Sokhadze, Joshua M. Baruth, Lonnie Sears, Guela E. Sokhadze, Ayman S. El-Baz, Manuel F. Casanova. Prefrontal neuromodulation using rTMS improves error monitoring and correction function in autism. Applied Psychophysiology & Biofeedback 2012 June; 37(2): 91–102.

Eric Gross, Ayman S. El-Baz, Guela E. Sokhadze, Lonnie Sears, Manuel F. Casanova, Estate M. Sokhadze. Induced EEG gamma oscillation alignment improves differentiation between autism and ADHD group responses in a facial categorization task. Journal of Neurotheraphy 2012 June; 16(2): 78–91.

Ahmed Elnakib, Manuel F. Casanova, Georgy Gimel’farb, Andrew E. Switala, Ayman El-Baz. Dyslexia diagnostics by 3-D shape analysis of the corpus callosum. IEEE transactions on information technology in biomedicine 2012 July; 16(4): 700–708

Manuel F. Casanova, Joshua M. Baruth, Ayman El-Baz, Allan Tasman, Lonnie Sears, Estate Sokhadze. Repetitive transcranial magnetic stimulation (rTMS) modulates event-related potential (ERP) indices of attention in autism. Translational neuroscience 2012 June; 3(2): 170–180.

Richard E. Frye, Manuel Casanova, Gregory L. Brown, Victoria Martin, Stephen Edelson, Robert Coben, Jeffrey Lewine, Daniel Rossignol, Derrick MacFabe, John Slattery, James B. Adams. A consensus statement from the Elias Tembenis Seizures Think Tanks. Autism science digest 2012 December; 5: 4–10.

Emily L. Williams, Manuel F. Casanova. Reassessment of teratogenic risk from antenatal ultrasound. Translational neuroscience 2013 March; 4(1): 81–87.

Emily L. Williams, Manuel F. Casanova, Andrew E. Switala, Hong Li, Mengsheng Qiu. Transposable elements occur more frequently in autism-risk genes: implications for the role of genomic instability in autism. Translational neuroscience 2013 June; 4(2): 172–202.

Richard E. Frye, Daniel Rossignol, Manuel F. Casanova, Gregory L. Brown, Victoria Martin, Stephen Edelson, Robert Coben, Jeffrey Lewine, John C. Slattery, Chrystal Lau, Paul Hardy, S. Hossein Fatemi, Timothy D. Folsom, Derrick MacFabe, James B. Adams. A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel. Frontiers in public health 2013 September 13; 1: 31.

Manuel F. Casanova, Ayman S. El-Baz, Shweta S. Kamat, Brynn A. Dombroski, Fahmi Khalifa, Ahmed Elnakib, Ahmed Soliman, Anita Allison-McNutt, Andrew E. Switala. Focal cortical dysplasias in autism spectrum disorders. Acta neuropathologica communications 2013 October 11; 1: 67.

Manuel F. Casanova. Canonical circuits of the cerebral cortex as enablers of neuroprosthetics. Frontiers in systems neuroscience 2013 November 8; 7: 77.

Brynn A. Dombroski, Matthew J. Nitzken, Ahmed A. Elnakib, Fahmi Khalifa, Andrew E. Switala, Ayman S. El-Baz, Manuel F. Casanova. Cortical surface complexity in a population-based normative sample. Translational neuroscience 2014 March; 5(1): 17–24.

F Zeidán-Chuliá, B-H Neves de Oliveira, A B Salmina, M F Casanova, D Pens Gelain, A Verkhratsky, J C Fonseca Moreira. Altered expression of Alzheimer’s disease related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy. Cell death & disease 2014 May 22; 5: e1250.

Ioan Opris, Manuel F. Casanova. Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing. Brain 2014 July; 137(7): 1863–1875.

Manuel F. Casanova. Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias. Medical hypotheses 2014 July; 83(1): 32–38.

Muthusamy Thangavel, Ratnam S. Seelan, Jaganathan Lakshmanan, Robert E. Vadnal, John I. Stagner, Latha K. Parthasarathy, Manuel F. Casanova, Rifaat Shody El-Mallakh, Ranga N. Parthasarathy. Proteomic analysis of rat prefrontal cortex after chronic valproate treatment. Journal of neuroscience research 2014 July; 92(7): 927–936.

Matthew J. Nitzken, Manuel F. Casanova, Georgy Gimel’farb, Tamer Inanc, Jacek M. Zurada, Ayman El-Baz. Shape analysis of the human brain: a brief survey. IEEE journal of biomedical and health informatics 2014 July; 18(4): 1337–1354.

Estate M. Sokhadze, Ayman S. El-Baz, Lonnie L. Sears, Ioan Opris, Manuel F. Casanova. rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism. Frontiers in systems neuroscience 2014 July 9; 8: 134.

Мануэл Ф. Казанова. Модульное устройство коры головного мозга: микроколонки и их патологии. Сибирский вестник специального образования 2014 August 26; 1(13): 9–13.

Ahmed Elnakib, Ahmed Soliman, Matthew Nitzken, Manuel F. Casanova, Georgy Gimel’farb, Ayman El-Baz. Magnetic resonance imaging findings for dyslexia: a review. Journal of biomedical nanotechnology 2014 October; 10(10): 2778–2805.

Manuel Fernando Casanova, Marie K. Hensley, Estate M. Sokhadze, Ayman S. El-Baz, Yao Wang, Xiaoli Li, Lonnie Sears. Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder. Frontiers in human neuroscience 2014 October 21; 8: 851.

Emily L. Casanova, Manuel F. Casanova. Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism. Frontiers in cellular neuroscience 2014 November 19; 8: 397.

Estate M. Sokhadze, Ayman S. El-Baz, Allan Tasman, Lonnie L. Sears, Yao Wang, Eva V. Lamina, Manuel F. Casanova. Neuromodulation integrating rTMS and neurofeedback for the treatment of autism spectrum disorder: an exploratory study. Applied psychophysiology and biofeedback 2014 December; 39(3–4): 237–257.

Lindsay M. Oberman, Peter G. Enticott, Manuel F. Casanova, Alexander Rotenberg, Alvaro Pascual-Leone, James T. McCracken. Transcranial magnetic stimulation (TMS) therapy for autism: an international consensus conference held in conjunction with the international meeting for autism research on May 13th and 14th, 2014. Frontiers in human neuroscience 2015 January 6; 8: 1034.

Manuel F. Casanova, Estate M. Sokhadze, Ioan Opris, Yao Wang, Xiaoli Li. Autism spectrum disorders: linking neuropathological findings to treatment with transcranial magnetic stimulation. Acta pædiatrica 2015 April; 104(4): 346–355.

Jerzy Wegiel, Michael Flory, N. Carolyn Schanen, Edwin H. Cook, Krzysztof Nowicki, Izabela Kuchna, Humi Imaki, Shuang Yong Ma, Jarek Wegiel, Eric London, Manuel F. Casanova, Thomas Wisniewski, W. Ted Brown Significant neuronal soma volume deficit in the limbic system in subjects with 15q11.2-q13 duplications. Acta neuropathologica communications 2015 October 13; 3: 63.

Jeffrey J. Hutsler, Manuel F. Casanova. Cortical construction in autism spectrum disorder: columns, connectivity and the subplate. Neuropathology and applied neurobiology 2015; in press.

Fares Zeidán-Chuliá, Ben-Hur Neves de Oliveira, Manuel F. Casanova, Emily L. Casanova, Mami Noda, Alla B. Salmina, Alexei Verkhratsky. Up-regulation of oligodendrocyte lineage markers in the cerebellum of autistic patients: evidence from network analysis of gene expression. Molecular neurobiology 2015; in press.

Yao Wang, Marie K. Hensley, Allan Tasman, Lonnie Sears, Manuel F. Casanova, Estate M. Sokhadze. Heart rate variability and skin conductance during repetitive TMS course in children with autism. Applied psychophysiology and biofeedback 2015; in press.

Amir Alansary, Marwa Ismail, Ahmed Soliman, Fahmi Khalifa, Matthew Nitzken, Ahmed Elnakib, Mahmoud Mostapha, Austin Black, Katie Stinebruner, Manuel F. Casanova, Jacek M. Zurada, Ayman El-Baz. Infant brain extraction in T1-weighted MR images using BET and refinement using LCDG and MGRF models. IEEE journal of biomedical and health informatics 2015; in press.

Estate M. Sokhadze, Allan Tasman, Guela E. Sokhadze, Ayman S. El-Baz, Manuel F. Casanova. Behavioral, cognitive, and motor preparation deficits in a visual cued spatial attention task in autism spectrum disorder. Applied psychophysiology and biofeedback 2016; in press.

Lindsay M. Oberman, Peter G. Enticott, Manuel F. Casanova, Alexander Rotenberg, Alvaro Pascual-Leone, James T. McCracken, TMS in ASD Consensus Group. Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research. Autism research 2016; in press.

Books

Manuel F. Casanova, ed. Neocortical modularity and the cell minicolumn. New York: Nova Biomedical Books; 2005 Sep 30.

Manuel F. Casanova, ed. Recent developments in autism research. New York: Nova Biomedical Books; 2005 Nov 30.

Jeffrey L. Rausch, Maria E. Johnson, Manuel F. Casanova, eds. Asperger’s disorder. New York: Informa Healthcare; 2008.

Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism. New York: Springer; 2013 May 31.

Manuel F. Casanova, Ioan Opris, editors. Recent advances on the modular organization of the cortex. New York: Springer; 2015 June 23.

Chapters and conference proceedings

Donald L. Price, Robert G. Struble, Peter J. Whitehouse, Cheryl A. Kitt, Linda C. Cork, Lary C. Walker, Manuel F. Casanova. Alzheimer’s disease: a multisystem disorder. In: Joseph B. Martin, Jack D. Barchas (ed.). Neuropeptides in neurologic and psychiatric disease. New York: Raven Press; 1986, 209–214.

Donald L. Price, Robert G. Struble, Cheryl A. Kitt, Linda C. Cork, Lary C. Walker, Manuel F. Casanova, Richard E. Powers. Neurobiological probes for specific constituents of senile plaques in aging and Alzheimer’s disease. In: George G. Glenner (ed.). Amyloidosis. New York: Plenum Press; 1986, 703–708.

G. William Moore, Richard A. Polacsek, Manuel F. Casanova, Yener S. Erozan, Johanna Hershey, Robert E. Miller, Grover M. Hutchins. Multilingual respelling rules for an English medical word list. In: Roger Salamon, Bruce Blum, Mogens Jørgensen, eds. MEDINFO 86. Amsterdam: North-Holland; 1986, 1106–1110.

Manuel F. Casanova, Richard C. Saunders, Lori L. Altshuler, Terry E. Goldberg, Este Armstrong, Daniel Roy Weinberger, Joel E. Kleinman. Entorhinal cortex pathology in schizophrenia and affective disorders. In: Giorgio Racagni, Nicoletta Brunello, Tetsuo Fukuda (ed.). Biological psychiatry. Amsterdam: Excerpta Medica; 1991, 1, 504–506.

Manuel F. Casanova, Atkinson DA, Terry E. Goldberg, Mark Zito, E. Fuller Torrey, Llewellyn B. Bigelow, Daniel Roy Weinberger. A quantitative study of the corpus callosum and cingulate cortex in schizophrenia: an MRI study. In: Giorgio Racagni, Nicoletta Brunello, Tetsuo Fukuda (ed.). Biological psychiatry. Amsterdam: Excerpta Medica; 1991, 2, 373–375.

Manuel F. Casanova, Janice R. Stevens, Joel E. Kleinman. The neuropathology of schizophrenia: old and new findings. In: Jean-Pierre Lindenmayer, Stanley R. Kay (ed.). New biological vistas on schizophrenia. New York: Brunner/Mazel; 1992, 82–109.

Joel E. Kleinman, Marc Laruelle, Jeffrey N. Joyce, Manuel F. Casanova. Abnormalities of serotonergic neural transmission in prefrontal cortex in schizophrenia. In: Philippe Robert, Guy Darcourt, Dominique Pringuey (eds.). Proceedings of the 18th Collegium Internationale Neuro-psychopharmacologicum congress. New York: Raven Press; 1992, 397A–398A.

Manuel F. Casanova, Daniel P. Buxhoeveden, Gurkirpal S. Sohal. Brain development and evolution. In: Monique Ernst, Judith M. Rumsey (ed.). Functional neuroimaging in child psychiatry. Cambridge: Cambridge University Press; 2000, 113–136.

Manuel F. Casanova. Anomalías en los circuitos corticales en los cerebros de pacientes con autismo. In: Juan Martos, Pedro Miguel González, María Llorente, Carmen Nieto, eds. Nuevos desarrollos en autismo: el futuro es hoy. Madrid: Librería Paradox; 2005 May, 345–371. [English version here]

Daniel Buxhoeveden, Manuel F. Casanova. The cell column in comparative anatomy. In: Manuel F. Casanova (ed.). Neocortical modularity and the cell minicolumn. New York: Nova Biomedical Books; 2005, 93–116.

Daniel Buxhoeveden, Manuel F. Casanova. Encephalization, minicolumns, and hominid evolution. In: Manuel F. Casanova (ed.). Neocortical modularity and the cell minicolumn. New York: Nova Biomedical Books; 2005, 117–136.

Manuel F. Casanova. Vernon B. Mountcastle: a life that transformed the neurosciences. In: Manuel F. Casanova (ed.). Neocortical modularity and the cell minicolumn. New York: Nova Biomedical Books; 2005, 1–13.

Manuel F. Casanova. An apologia for a paradigm shift in the neurosciences. In: Manuel F. Casanova (ed.). Neocortical modularity and the cell minicolumn. New York: Nova Biomedical Books; 2005, 33–55.

Manuel F. Casanova, Andrew E. Switala. Minicolumnar morphometry: computerized image analysis. In: Manuel F. Casanova (ed.). Neocortical modularity and the cell minicolumn. New York: Nova Biomedical Books; 2005, 161–179.

Juan Trippe II, Manuel F. Casanova. Vernon B. Mountcastle: scientific achievements. In: Manuel F. Casanova (ed.). Neocortical modularity and the cell minicolumn. New York: Nova Biomedical Books; 2005, 15–32.

Anouar I. Konkachbaev, Adel S. Elmaghraby, Manuel F. Casanova. Recursive segmentation of minicolums using myelinated bundles. In: Engineering in Medicine and Biology Society. Neural engineering 2005: conference proceedings. Piscataway, N.J.: IEEE; 2005, 52–55.

A.I. Konkachbaev, M.F. Casanova, J.H. Graham, A.S. Elmaghraby. Automated recursive segmentation of large neocortical images using standard deviation as termination criteria. In: Engineering in Medicine and Biology Society. 27th International Conference of the IEEE Engineering in Medicine and Biology Society. Piscataway, N.J.: IEEE; 2005, 2531–2534.

Manuel F. Casanova. Minicolumnar pathology in autism. In: Manuel F. Casanova (ed.). Recent developments in autism research, 133–143. New York: Nova Biomedical Books; 2005 Nov 30.

Noha El-Zehiry, Manuel Casanova, Hossam Hassan, Aly Farag. Effect of minicolumnar disturbance on dyslexic brains: an MRI study. In: IEEE Engineering in Medicine and Biology Society. Biomedical imaging: macro to nano. Piscataway, N.J.: IEEE; 2006 May, 1336–1339.

Latha K. Parthasarathy, Ratnam S. Seelan, Carmelita R. Tobias, Manuel F. Casanova, Ranga N. Parthasarathy. Mammalian inositol 3-phosphate synthase: its role in the biosynthesis of brain inositol and its clinical use as psychoactive agent. In: Aron Lahiri Majumder, B.B. Biswas, editors. Biology of inositols and phosphoinositides, 291-312. New York: Springer, 2006 Jul 21.

Ayman El-Baz, Aly Farag, Asem Ali, Georgy Gimel’farb, Manuel Casanova. A framework for unsupervised segmentation of multi-modal medical images. In: Reinhard R. Beichel, Milan Sonka, eds. Computer vision approaches to medical image analysis, 120–131. New York: Springer, 2006 Nov.

Manuel F. Casanova. Cortical circuit abnormalities in the brains of autistic patients. In: Juan Martos Pérez, Pedro M. González, María Llorente Comí, Carmen Nieto, eds. New developments in autism: the future is today, 267–288. London: Jessica Kingsley Publishers, 2006 Dec 30.

Ayman El-Baz, Manuel F. Casanova, Georgy Gimel’farb, Meghan Mott, Andrew E. Switala. A new image analysis approach for automatic classification of autistic brains. In: Biomedical imaging: From nano to macro. Piscataway, NJ: IEEE; 2007, 352-355.

Rachid Fahmi, Ayman S. El-Baz, Hossam E. Abd El Munim, Aly A. Farag, Manuel F. Casanova. Classification techniques for autistic vs. typically developing brain using MRI data. In: Biomedical imaging: From nano to macro. Piscataway, NJ: IEEE; 2007 May, 1348-1351.

Rachid Fahmi, Ayman Elbaz, Hossam Hassan, Aly A. Farag, Manuel F. Casanova. Structural MRI-based discrimination between autistic and typically developing brain. International journal of computer assisted radiology and surgery 2007 June; 1(Supplement 1): S24–S26.

H. Abd El Munim, R. Fahmi, N. Youssry El-Zehiry, A.A. Farag, M. Casanova. Volumetric MRI analysis of dyslexic subjects using a level set framework. In: Jasjit S. Suri, Aly Farag, eds. Deformable models: theory and biomaterial applications. New York: Springer-Verlag; 2007 Aug 3, 461–492.

Rachid Fahmi, Ayman El-Baz, Hossam Abd El-Munim, Alaa E. Abdel-Hakim, Aly A. Farag, Manuel F. Casanova. Robust neuroimaging-based classification techniques of autistic vs. typically developing brain. In: Jasjit S. Suri, Aly Farag, eds. Deformable models: theory and biomaterial applications. New York: Springer-Verlag; 2007 Aug 3, 535–566.

Sarah B. Johnson, Somnath Datta, Carlton A. Hornung, Manuel F. Casanova. Mathematical models of epigenetic influences in autism: a new perspective based on neuropathological findings. In: Paul C. Carlisle, ed. Progress in autism research. New York: Nova Biomedical; 2007 Oct, 101–114.

Ayman El-Baz, Manuel F. Casanova, Georgy Gimel`farb, Meghan Mott, Andrew E. Switala. Autism diagnostics by 3D texture analysis of cerebral white matter gyrifications. In: Nicholas Ayache, Sébastien Ourselin, Anthony J. Maeder, eds. Medical image computing and computer-assisted intervention—MICCAI 2007, part II. Lecture Notes in Computer Science 2007 November; 4792: 882–890.

Hossam Abd EL Munim, Aly A. Farag, Manuel F Casanova. Frequency-domain analysis of the human brain for studies of autism. In: ISSPIT 2007. Piscataway, N.J.: IEEE; 2007 Dec 15, 1198–1203.

Noha El-Zehiry, Manuel Casanova, Adel Elmaghraby. Variability of the relative corpus callosum cross sectional area between dyslexic and normally developed brains. In: Biomedical imaging: From nano to macro. Piscataway, NJ: IEEE; 2008 May 14, 436–439.

Manuel F. Casanova. Neuropathological findings in Asperger syndrome. In: Jeffrey L. Rausch, Marie E. Johnson, Manuel F. Casanova, eds. Asperger’s disorder. New York: Informa Healthcare; 2008 Aug 12, 155–170.

Manuel F. Casanova. The significance of minicolumnar size variability in autism: a perspective from comparative anatomy. In: Andrew W. Zimmerman, ed. Autism: Current theories and evidence. Totowa, N.J.: Humana Press; 2008 Oct 15, 349–360.

A. El-Baz, M. Casanova, G. Gimel’farb, M. Mott, A. Switala, E. Vanbogaert, R. McCracken. A new CAD system for early diagnosis of dyslexic brains. IEEE International Conference on Image Processing 2008 Oct 14; 15: 1820–1823.

A. El-Baz, M. Casanova, G. Gimel’farb, M. Mott, A. Switala, E. Vanbogaert, R. McCracken. Dyslexia diagnostics by 3D texture analysis of cerebral white matter gyrifications. IEEE International Conference on Pattern Recognition 2008 Dec 8; 19. DOI: 10.1109/ICPR.2008.4760971.

Sarah B. Johnson, Manuel F. Casanova. Interhemispheric connectivity: the evolution and nature of the corpus callosum. In: Timothy B. Westland, Robert N. Calton, eds. Handbook on white matter: structure, function, and changes, 3–15. Hauppauge: Nova Science Publishers; 2009 Jul 28.

Fabián Crespo, Rafael Fernandez-Botrán, Christopher Tillquist, Lonnie Sears, Meghan Mott, Manuel Casanova. Cytokine polymorphisms in autism: their role in immune alterations. In: Abha Chauhan, Ved Chauhan, W. Ted Brown, eds. Autism: Oxidative stress, inflammation, and immune abnormalities, 315–324. Boca Raton: CRC Press; 2009 Oct 14.

Joshua Baruth, Estate Sokhadze, Ayman El-Baz, Grace Mathai, Lonnie Sears, Manuel F. Casanova. Transcranial magnetic stimulation. In: Ken Siri, Tony Lyons, eds. Cutting-edge therapies for autism: 2010–2011, 388–397. New York: Skyhorse Publishing; 2010 Apr 1.

Manuel Casanova, Estate Sokhadze, Ayman El-Baz, Joshua Baruth, Grace Mathai, Lonnie Sears. Research at the University of Louisville Autism Center. In: Ken Siri, Tony Lyons, eds. Cutting-edge therapies for autism: 2010–2011, 410–413. New York: Skyhorse Publishing; 2010 Apr 1.

Ahmed Elnakib, Ayman El-Baz, Manuel F. Casanova, Georgy Gimel’farb, Andrew E. Switala. Image-based detection of corpus callosum variability for more accurate discrimination between dyslexic and normal brains. IEEE international symposium on biomedical imaging: From nano to macro. 2010 Apr 14; 7: 109–112.

Ahmed Elnakib, Ayman El-Baz, Manuel F. Casanova, Andrew E. Switala. Dyslexia diagnostics by centerline-based shape analysis of the corpus callosum. Proceedings of the International Conference on Pattern Recognition 2010 Aug 23; 20: 261–264.

Ahmed Farag, Shireen Elhabian, Mostafa Abdelrahman, James Graham, Aly Farag, Dongqing Chen, Manuel F. Casanova. Shape modeling of the corpus callosum. Proceedings of the International Conference of the IEEE Engineering in Medicine and Biology Society 2010 September 3; 32: 4288–4291.

Ahmed Elnakib, Ayman El-Baz, Manuel F. Casanova, Georgy Gimel’farb, Andrew E. Switala. Image-based detection of corpus callosum variability for more accurate discrimination between autistic and normal brains. IEEE International Conference on Image Processing 2010 September 26; 17: 4337–4340.

Ahmed Farag, Shireen Elhabian, Mostafa Abdelrahman, James Graham, Aly Farag, Dongqing Chen, Manuel F. Casanova. Surface modeling of the corpus callosum from MRI scans. In: Advances in visual computing: 6th International Symposium, ISVC 2010, Las Vegas, NV, USA, November 29-December 1, 2010, proceedings, in press. New York: Springer; 2010 December 13.

M. Nitzken, M. F. Casanova, G. Gimel’farb, A. Elnakib, F. Khalifa, A. Switala, A. El-Baz. 3D shape analysis of the brain cortex with application to autism. IEEE international symposium on biomedical imaging: From nano to macro. 2011 Mar 30; 8: 1847–1850.

A. Elnakib, M. F. Casanova, G. Gimel’farb, A. E. Switala, A. El-Baz. Autism diagnostics by centerline-based shape analysis of the corpus callosum. IEEE international symposium on biomedical imaging: From nano to macro. 2011 Mar 30; 8: 1843–1846.

Joshua Baruth, Estate Sokhadze, Ayman El-Baz, Grace Mathai, Lonnie Sears, Manuel F. Casanova. Transcranial magnetic stimulation as a treatment for autism. In: Ken Siri, Tony Lyons, eds. Cutting-edge therapies for autism: 2011–2012, 402–411. New York: Skyhorse Publishing; 2011 April.

Manuel F. Casanova, Estate Sokhadze, Ayman El-Baz, Joshua Baruth, Grace Mathai, Lonnie Sears. Research at the University of Louisville Autism Center. In: Ken Siri, Tony Lyons, eds. Cutting-edge therapies for autism: 2011–2012, 425–429. New York: Skyhorse Publishing; 2011 April.

Matthew Nitzken, Manuel F. Casanova, Fahmi Khalifa, Guela Sokhadze, Ayman El-Baz. Shape-based detection of cortex variability for more accurate discrimination between autistic and normal brains. In: Ayman S. El-Baz, Rajendra Acharya U, Andrew F. Laine, Jasjit S. Suri, eds. Multi modality state-of-the-art medical image segmentation and registration methodologies, 161–185. New York: Springer; 2011 May 12.

M. Nitzken, M. Casanova, G. Gimel’farb, A. Elnakib, F. Khalifa, A. Switala, and A. El-Baz. 3D shape analysis of the brain cortex with application to dyslexia. IEEE International Conference on Image Processing 2011 September 11; 18: 2657–2660.

Ahmed Elnakib, Manuel F. Casanova, Georgy Gimel’farb, Ayman El-Baz. Autism diagnostics by 3D shape analysis of the corpus callosum. In: Kenji Suzuki, editor. Machine learning in computer-aided diagnosis: medical imaging intelligence and analysis, 315–335. Hershey: Medical Information Science Reference; 2012 January 31.

Meghan C. Mott, Rafael Fernandez-Botrán, Manuel F. Casanova. Neuroinflammation in the pathogenesis of Autism Spectrum Disorders: converging evidence for systemic and central nervous system immune interaction. In: Owen B. Williams, Garet I. Wilson, editors. Advances in brain research, in press. New York: Nova Biomedical Books; 2012 September 30.

Manuel F. Casanova. The minicolumnopathy of autism. In: Joseph D. Buxbaum, Patrick R. Hof, editors. The neuroscience of autism spectrum disorders, 327–334. Amsterdam: Academic Press; 2012 November 5.

Meghan C. Mott, Rafael Fernandez-Botrán, Manuel F. Casanova. Neuroinflammation in the pathogenesis of Autism Spectrum Disorders: converging evidence for systemic and central nervous system immune interaction. In: Carmelina Gemma, editor. Neuroinflammation: pathogenesis, mechanisms and management, 149–179. New York: Nova Biomedical Books; 2012 November 30. Neuroscience research progress

Manuel F. Casanova. Neural mechanisms in autism. In: Fred Volkmar, ed. Encyclopedia of autism spectrum disorders, 1994–2007. Heidelberg: Springer; 2013 April 2.

Manuel F. Casanova, Paul H. Patterson, Eric London. Introduction to neuropathology. In: Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism, 1–26. New York: Springer; 2013 May 31.

Manuel F. Casanova, Jane Pickett. The neuropathology of autism. In: Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism, 27–43. New York: Springer; 2013 May 31.

Estate M. Sokhadze, Joshua Baruth, Allan Tasman, Manuel F. Casanova. Event-related potential studies of cognitive processing abnormalities in autism. In: Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism, 61–86. New York: Springer; 2013 May 31.

Manuel F. Casanova, Joshua Baruth, Ayman S. El-Baz, Guela E. Sokhadze, Marie Hensley, Estate M. Sokhadze. Evoked and induced gamma-frequency oscillations in autism. In: Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism, 87–106. New York: Springer; 2013 May 31.

Estate M. Sokhadze, Manuel F. Casanova, Joshua Baruth. Transcranial magnetic stimulation in autism spectrum disorders. Lucia Alba-Ferrara, editor. Transcranial magnetic stimulation: methods, clinical uses and effects on the brain, 219–231. Hauppauge: Nova Science Publishers; 2013 August 22.

Steven A. Chance, Manuel F. Casanova. Auditory cortex asymmetry and language processing in schizophrenia. In: Paolo Brambilla, Andrea Marini, editors. Brain evolution, language, and psychopathology in schizophrenia, 53–72. London: Psychology Press; 2013 October 23. Explorations in mental health.

Manuel F. Casanova, Brynn Dombroski, Andrew E. Switala. Imaging and the corpus callosum in patients with autism. In: Vinood B. Patel, Victor R. Preedy, Colin R. Martin, editors. The comprehensive guide to autism, 947–962. Berlin: Springer; 2013 October 30.

Manuel F. Casanova. The neuropathology of autism. In: Fred R. Volkmar, Rhea Paul, Sally J. Rogers, Kevin A. Pelphrey, editors. Handbook of autism and pervasive developmental disorders, fourth edition, 497–531. New York: Wiley; 2014 March 3.

Mahmoud Mostapha, Amir Alansary, Ahmed Soliman, Fahmi Khalifa, Matthew Nitzken, Rasha Khodeir, Manuel F. Casanova, Ayman El-Baz. Atlas-based approach for the segmentation of infant DTI MR brain image. IEEE international symposium on biomedical imaging: From nano to macro 2014 Apr 29; 11: 1255–1258.

Manuel F. Casanova, Estate M. Sokhadze. Transcranial magnetic stimulation: application in autism treatment. In: Valerie W. Hu, editor. Frontiers in autism research: new horizons for diagnosis and treatment, 583–606. Hackensack: World Scientific Publishing; 2014 July 7.

Mahmoud Mostapha, Ahmed Soliman, Fahmi Khalifa, Ahmed Elnakib, Amir Alansary, Matthew Nitzken, Manuel F. Casanova, Ayman El-Baz. A statistical framework for the classification of infant DT images. IEEE International Conference on Image Processing 2014 October 27; 21: 2222–2226.

A. Alansary, A. Soliman, M. Nitzken, F. Khalifa, A. Elnakib, M. Mostapha, M. F. Casanova, A. El-Baz. An integrated geometrical and stochastic approach for accurate infant brain extraction. IEEE International Conference on Image Processing 2014 October 27; 21: 3542–3546.

Manuel F. Casanova. La neurobiología del autismo. In: María Merino Martínez, editor. Todo sobre el Asperger, 53–76. Tarragona: Altaria; 2014 December 1.

Emily L. Williams, Manuel F. Casanova. Ultrasound and autism: how disrupted redox homeostasis and transient membrane porosity confer risk. In: Anna Dietrich-Muszalska, Ved Chauhan, Sylvain Grignon, editors. Studies on psychiatric disorders, 373–392. New York: Humana Press; 2015 January 17. Donald Armstrong, series editor. Oxidative stress in applied basic research and clinical practice.

Manuel F. Casanova. The neuropathology of autism. In: S. Hossein Fatemi, editor. The molecular basis of autism, 153–171. New York: Springer; 2015 April 15. Mario Manto, series editor. Contemporary clinical neuroscience.

Published abstracts

Manuel F. Casanova, Juan C. Troncoso, Donald L. Price. Hematogenous origin of brain macrophages. Neurology 1984 March 1; 34(3 suppl. 1), 83.

Manuel F. Casanova, Robert G. Struble, Linda C. Cork, Donald L. Price. Senile plaques in Alzheimer’s Disease: new approaches for their detection. Annals of neurology 1984 July; 16(1), 119.

Manuel F. Casanova, Peter J. Whitehouse, Robert G. Struble, Donald L. Price. Historical perspective on our concepts of the senile plaque. Annals of neurology 1984; 16(1), 134.

Manuel F. Casanova, Robert G. Struble, Glaser EM, Richard E. Powers, Peter J. Whitehouse, Tagamets M, Donald L. Price. Distribution of plaques and tangles in the hippocampi of patients with Alzheimer’s disease. Neurology 1985 April 1; 35(4 suppl. 1), 183.

Manuel F. Casanova, Juan C. Troncoso, Donald L. Price. Cerebral hemorrhagic infarcts: an autopsy study of 76 cases. Neurology 1985 April 1; 35(4 suppl. 1), 186.

R.E. Powers, R.G. Struble, M.F. Casanova, C.A. Kitt, D.T. O’Connor, D.L. Price. Immunocytochemical localization of putative neurotransmitter substances in human hippocampus. Journal of neuropathology and experimental neurology 1985 May; 44(3), 324.

R.G. Struble, R.E. Powers, M.F. Casanova, C.A. Kitt, D.T. O’Connor, D.L. Price. Multiple transmitter-specific markers in senile plaques in Alzheimer’s disease. Journal of neuropathology and experimental neurology 1985 May; 44(3), 325.

D.L. Price, R.G. Struble, R.J. Altschuler, M.F. Casanova, L.C. Cork, D.B. Murphy. Aggregation of tubulin in neurons in Alzheimer’s disease. Journal of neuropathology and experimental neurology 1985 May; 44(3), 366.

L.C. Cork, R.J. Altschuler, R.G. Struble, M.F. Casanova, D.L. Price, N. Sternberger, L. Sternberger. Changes in the distribution of phosphorylated neurofilaments in Alzheimer’s disease. Journal of neuropathology and experimental neurology 1985 May; 44(3), 368.

Richard M. Zweig, Peter J. Whitehouse, Manuel F. Casanova, Lary C. Walker, William R. Jankel, Donald L. Price. Loss of putative cholinergic neurons of the pedunculopontine nucleus in progressive supranuclear palsy. Annals of neurology 1985 Jul; 18(1), 144.

R.M. Zweig, W.R. Jankel, P.J. Whitehouse, M.F. Casanova, J.C. Hedreen, D.L. Price. Brainstem pathology in dystonia. Neurology 1986; 36(4), 74–75.

Donald L. Price, Robert G. Struble, Richard E. Powers, Manuel F. Casanova, Cheryl A. Kitt, P.J. Whitehouse, Linda C. Cork. Neuropathological correlates of dementia in Alzheimer’s disease. In: Charles Shagass, et al. (eds.) Biological psychiatry 1985. New York: Elsevier, 1986.

Harvey S. Singer, Paul Slesinger, Pedro Lowenstein, Larry Walker, Manuel Casanova, Donald Price, Joseph Coyle. The maturation of pre- and postsynaptic neurotransmitter markers in baboon striatum. Annals of neurology 1986; 20(3), 430.

Manuel F. Casanova, Lary C. Walker, Donald L. Price. Intraventricular lipoma in a human fetus of 17 weeks gestation. Neurology 1987; 37(3), 90.

Manuel F. Casanova, Robert G. Struble, Peter J. Whitehouse, Donald L. Price. Senile dementia: significant findings at the turn of the century and comparison with present-day knowledge. Neurology 1987; 37(3), 216–217.

L. Altschuler, J. Stevens, M. Casanova, C. Stevens, B. Bogerts, P. Falkai, L. Germain, C. Buchan. Is there gliosis in schizophrenia? comparison of techniques. Schizophrenia research 1988; 1(2–3), 153–154.

Manuel F. Casanova, Richard C. Saunders, Nicholas W. Carosella, Daniel Roy Weinberger. Prepyriform cortex abnormalities in schizophrenia. Continuing medical education syllabus and scientific proceedings in summary form 1989; 142, 65.

MF Casanova, J Stevens. Astrocytosis of the “extended amygdala” in schizophrenia. Schizophrenia research 1989; 2(1–2), 97.

MF Casanova, DG Daniel, TE Goldberg, Rl Suddath, DR Weinberger. Shape analysis of the middle cranial fossa of schizophrenic patients: a computerized tomographic study. Schizophrenia research 1989; 2(1–2), 133.

MF Casanova, T Hyde, N Carosella, DR Weinberger, JE Kleinman. Concordance of familial nonarteriosclerotic mineralization of the basal ganglia and schizophrenia in two generations: a case report. Schizophrenia research 1989; 2(1–2), 134.

DG Daniel, D Kostianovsky, E Kim, T Goldberg, M Casanova, J Kleinman, D Weinberger. Brain density in schizophrenia. Schizophrenia research 1989; 2(1–2), 135.

Ana Hitri, Manuel F. Casanova, Joel E. Kleinman, Richard Jed Wyatt. Characterization of 3H-GBR 12935 binding to the dopamine transporter in human frontal cortex and its relevance to schizophrenia. Schizophrenia research 1989; 2(1–2), 100.

W. G. Honer, C. A. Kaufmann, J. E. Kleinman, M. Casanova, P. Davies. A new approach to the neurobiology of schizophrenia using monoclonal antibodies. Schizophrenia research 1989; 2(1–2), 101.

CM Prasad, MF Casanova, B Stein, B Illowsky, DR Weinberger, JE Kleinman. Basal ganglia mineralization in schizophrenia. Schizophrenia research 1989; 2(1–2), 139.

R. L. Suddath, G. Christison, E. F. Torrey, M. D. Casanova, D. R. Weinberger. Quantitative magnetic resonance imaging in twin pairs discordant for schizophrenia. Schizophrenia research 1989; 2(1–2), 129.

Manuel F. Casanova, Thomas M. Hyde, Terry E. Goldberg, Daniel R. Weinberger, Joel E. Kleinman. Ventral tegmental pathology in schizophrenia. New research abstracts: annual meeting of the American Psychiatric Association 1989 May; 142, 79.

Nicholas W. Carosella, Manuel F. Casanova, E. Fuller Torrey, Daniel R. Weinberger. Quantization of iron in the globus pallidus of monozygotic twins discordant for schizophrenia: an MRI study. Biological psychiatry 1989; 25(7A), 16A.

Manuel F. Casanova, Richard Saunders, Jan Stevens, Joel E. Kleinman. Quantitation of astrocytes in the molecular layer of the dentate gyrus in schizophrenic patients. Biological psychiatry 1989; 25(7A), 58A.

Manuel F. Casanova, Nicholas Carosella, Joel E. Kleinman. Midbrain tegmental pathology in a case of childhood schizophrenia. Biological psychiatry 1989; 25(7A), 59A.

Manuel F. Casanova, Terry E. Goldberg, Sakkubai Naidu, Suzan Khoromi, Ashok Kumar, Daniel R. Weinberger, Hugo W. Moser. Quantitative analysis of magnetic resonance imaging in Retts syndrome. Biological psychiatry 1989; 25(7A), 64A.

Ana Hitri, Hung Q. Nguyen, Manuel F. Casanova, Joel E. Kleinman, Daniel R. Weinberger, Richard Jed Wyatt. Characterization of dopamine uptake sites in the human and rat frontal cortex. Biological psychiatry 1989; 25(7A), 51A.

Nedra Lexow, Roman Artymyshyn, Manual Cassanova, Andrew Winokur, Joel Kleinman, Jeffrey Joyce. Alterations in bilateral distribution of beta-adrenergic receptor subtypes in schizophrenia and suicide. Biological psychiatry 1989; 25(7A), 197A.

Daniel Roy Weinberger, Richard L. Suddath, Manuel F. Casanova, George W. Christison, E. Fuller Torrey. Morphometric studies of brain anatomy with MRI in normal monozygotic twins and monozygotic twins discordant for schizophrenia. Clinical neuropharmacology 1990; 13(2), 164–165.

R. C. Alexander, S. A. Spector, M Casanova, J Kleinman, R. J. Wyatt, D Kirch. Search for cytomegalovirus in the post-mortem brains of schizophrenic patients using the polymerase chain reaction. Schizophrenia research 1990; 3(1), 89.

M Laurelle, M Casanova, D. R. Weinberger, J. Kleinman. Postmortem study of the dopaminergic d1 receptors in the dorsolateral prefrontal cortex of schizophrenics and controls. Schizophrenia research 1990; 3(1), 30–31.

Manuel F. Casanova, Joel E. Kleinman. Staining intensity of brain iron in patients with schizophrenia: a postmortem study. Biological psychiatry 1990; 27(9A), 111A.

Manuel F. Casanova, Amitava Biswas, Joel E. Kleinman. Alterations of pineal alpha1-adrenergic receptors in suicides and chronic undifferentiated schizophrenic patients. Biological psychiatry 1990; 27(9A), 111A–112A.

Ana Hitri, Manuel F. Casanova, Joel E. Kleinman, Daniel R. Weinberger, Richard Jed Wyatt. Relevance of dopamine transporter binding in the frontal cortex to schizophrenia. Biological psychiatry 1990; 27(9A), 51A.

Kunimasa Arima, Manuel F. Casanova, William G. Honer, Charles A. Kaufmann, Peter Davies, Joel E. Kleinman. EP10 immunohistochemistry in control and schizophrenic brains. Biological psychiatry 1991; 29(9A), 47A.

Manuel F. Casanova, Rosanne Toti, Daniel Weinberger, Joel E. Kleinman. Pyramidal cell disarray in the hippocampus of schizophrenic patients. Biological psychiatry 1991; 29(9A), 89A.

Manuel F. Casanova, Kunimasa Arima, Joel E. Kleinman. A study on the mass lesion effect of senile plaques. Biological psychiatry 1991; 29(9A), 122A.

Manuel F. Casanova, Thomas Hyde. Symptomatic mineralization of brain vessels: its relevance to psychiatry research. Biological psychiatry 1991; 29(9A), 172A.

Ana Hitri, Manuel E. Casanova, Joel E. Kleinman, Richard J. Wyatt. Decreased dopamine transport receptors in the frontal cortex of cocaine addicts. Biological psychiatry 1991; 29(9A), 183A–184A.

Jeffrey N. Joyce, Manuel Casanova, Joel Kleinman. Serotonin innervation and receptor changes in striatum and cortex of schizophrenics. Biological psychiatry 1991; 29(9A), 90A.

Craig N. Karson, Edgar Garcia-Rill, W. Sue Griffin, Robert Mrak, Muhammad Husain, Manuel Casanova. The brainstem reticular formation in schizophrenia. Biological psychiatry 1991; 29(9A), 90A.

Michael B. Knable, Manuel F. Casanova, Mark Zito, Matthias I. Okoye, Vincent Hill, Daniel R. Weinberger, Joel E. Kleinman. Distribution of dopamine reuptake sites in the human brain: a whole brain autoradiographic study with [3H]CFT. Biological psychiatry 1991; 29(9A), 158A.

Bhaskar S. Kolachana, Manuel F. Casanova, Joel E. Kleinman. A postmortem study of melatonin and other indoles in the pineal glands of suicides, schizophrenics and controls. Biological psychiatry 1991; 29(9A), 91A.

Manuel F. Casanova. Recent MRI findings on corpus callosum morphometry in schizophrenia. Biological psychiatry 1991; 29(11S), 12S–13S.

Manuel F. Casanova. The neuropathology of schizophrenia: NIMH studies. Biological psychiatry 1991; 29(11S), 61S.

Manuel F. Casanova, Thomas Hyde. Brainstem pathology in Alzheimer’s disease patients with psychotic symptomatology. Biological psychiatry 1992; 31(5A), 150A.

Manuel F. Casanova, Mark Zito, Lori Altschuler, Daniel R. Weinberger, Joel E. Kleinman. Nucleolar size of entorhinal cortex cells in patients with schizophrenia. Biological psychiatry 1992; 31(5A), 206A.

Manuel F. Casanova, Silvia O. Comparini, Bhaskar Kolachana, Joel E. Kleinman. Neurochemical abnormalities in the brains of sudden infant death syndrome (SIDS) patients exposed in utero to cocaine. Biological psychiatry 1992; 31(5A), 242A.

L.S. Holsenbeck, Laura Davidson, Robin Hostetter, Manuel Casanova, David Schenk, Walter Duffy, Bruce Diamond. Positive and negative symptom syndromes and ventricular brain ratio (VBR) at the onset of schizophreniform disorder. Biological psychiatry 1992; 31(5A), 122A.

L.S. Holsenbeck, Laura Davidson, Robin Hostetter, Manuel Casanova, David Taylor, Colin Kelley, Charles Perrotta, Richard Borison. Ventricular brain ratio (VBR) at the onset of first-break psychosis. Biological psychiatry 1992; 31(5A), 123A.

Manuel F. Casanova, Daniel Roy Weinberger, E. Fuller Torrey, Bugao Xu, J. Sobus, Behnam Pourdeyhimi. Focal temporal lobe abnormalities in schizophrenia. Continuing medical education syllabus and scientific proceedings in summary form 1992; 145, 147.

M.F. Casanova, M. Kruesi, G. Mannheim. Multiple sclerosis and bipolar disorder: a case report with autopsy findings. Biological psychiatry 1993; 33(6A), 78A.

M.F. Casanova, E. Fuller Torrey, N. De Vaughn. Corpus callosum dimorphism in monozygotic twins. Biological psychiatry 1993; 33(6A), 160A.

M.J.P. Kruesi, M. Casanova, G. Mannheim, J.M. Rumsey, A. Johnson, S.D. Hamburger. Regional brain volumes in children and adolescents with conduct disorders at high risk for antisocial personality disorder. Biological psychiatry 1993; 33(6A), 114A.

Manual F. Casanova, Nathan M. DeVaughn. Temporal lobe pathology in schizophrenia and its relation to brain shifts in magnetic resonance imaging. Schizophrenia research 1993; 9(2–3), 196.

Ana Hitri, Manuel F. Casanova, Stephen I. Deutsch, Richard J. Wyatt. Effects of maturation on the dopamine transporter. Transactions of the American Society for Neurochemistry 1994; 25(1), 60a.

Matsunaga T, Shimada A, Alexey G. Mukhin, Donald K. Ingram, Zukin SR, Joel E. Kleinman, Manuel F. Casanova, Edythe D. London. NMDA receptor domains in postmortem brains of schizophrenic patients. Abstracts: Society for Neuroscience 1995; 21, §2125.

M.F. Casanova, J.R. Stevens, R. Brown, C. Royston, C. Bruton. Glial fibrillary tangles in patients with late-onset schizophrenia. Biological psychiatry 2000; 47(8), 152S.

M.F. Casanova, D. Buxhoeveden, J.R. Stevens, R. Brown, C. Royston, C. Bruton. Neurofibrillary tangles and pyramidal cell counts in paraphrenia. Biological psychiatry 2000; 47(8), 152S.

M.F. Casanova, E. Lindzen, A. Pathiraja, J.R. Stevens, R. Brown, C. Royston, C. Bruton. White gray matter ratios in the parahippocampal gyrus of paraphrenia. Biological psychiatry 2000; 47(8), 152S.

M.F. Casanova, D. Buxhoeveden, A. Switala, E. Roy. Reduced neuropil in the auditory cortex of patients with schizophrenia. Biological psychiatry 2000; 47(8), 152S–153S.

M.F. Casanova, D. Buxhoeveden, A. Switala, E. Roy. Lateralization of Tpt minicolumns in patients with schizophrenia. Biological psychiatry 2000; 47(8), 153S.

M.F. Casanova, J.R. Stevens, R. Brown, C. Royston, C. Bruton. Restricted limbic tauopathy in patients with late-onset schizophrenia. Biological psychiatry 2000; 47(8), 153S.

Manuel F. Casanova, Daniel P. Buxhoeveden, Janice R. Stevens, Rosemary Brown, Claire Royston, Clive J. Bruton. Abundant neurofibrillary tangles and absent pyramidal cell loss in the hippocampus of patients with late onset schizophrenia. 2001

Manuel F. Casanova, Daniel P. Buxhoeveden, Andrew Edward Switala, Emil Roy. The neuropathology of dyslexia: a case report. 2001

M.F. Casanova, D. Buxhoeveden, A.E. Switala, E. Roy. Anomalies in the cortical processing units of the autistic brain. Biological psychiatry 2001; 49(8), 98S.

M.F. Casanova, D. Buxhoeveden, A.E. Switala, E. Roy. Minicolumnar pathology in Asperger’s syndrome. Biological psychiatry 2001; 49(8), 158S.

M. F. Casanova, A. Pathiraja, D. Buxhoeveden, A. Switala, E. Roy. Comparative lateralization of minicolumns in normal human and schizophrenic brains. Schizophrenia research 2001; 49(2), 60.

Daniel Buxhoeveden, Manuel F. Casanova. Computer modeling of excitation-inhibition defects in autism. New research abstracts: annual meeting of the American Psychiatric Association 2001; 154, §728.

Manuel F. Casanova. Gray level index abnormalities in the brains of autistic patients. New research abstracts: annual meeting of the American Psychiatric Association 2001; 154, §726.

D. Buxhoeveden, K. Semendeferi, M. Casanova. Lateralization of minicolumns in human planum temporale is absent in nonhuman primate cortex. American journal of physical anthropology 2002; 117(S34), 51.

Manuel F. Casanova, Daniel P. Buxhoeveden, Andrew Edward Switala, Emil Roy. Minicolumnar pathology in the brains of autistic and Asperger’s patients. Neurology 2002; 58(7), A2–A3.

Manuel F. Casanova, Janice R. Stevens, Rosemary Brown, Claire Royston, Clive Bruton. Disentangling the pathology of schizophrenia and paraphrenia. Neurology 2002; 58(7), A356–A357.

Daniel P. Buxhoeveden, Manuel F. Casanova. Brain disorders in human evolution. American journal of physical anthropology 2003; 120(S36), 73.

Manuel F. Casanova, Anuar Isak Konkachbaev, Andrew Edward Switala, Adel S. Elmaghraby, Juan Trippe II, Archibald J. Fobbs Jr. Identification of pyramidal cell arrays using Delaunay triangulation. .

Manuel F. Casanova, Andrew Edward Switala, Juan Trippe II, Archibald J. Fobbs Jr. The modular organization of the brain: a postmortem case report on three distinguished neuroscientists. .

Manuel F. Casanova, Andrew Edward Switala, Juan Trippe II, Archibald J. Fobbs Jr. A comparison study of the vertical bias in neocortex and hippocampus. .

Manuel F. Casanova, Julio Araque, Jay N. Giedd, Judith M. Rumsey. Reduced brain size and gyrification in the brains of dyslexic patients. Biological psychiatry 2004; 55(8), 15S.

Manuel F. Casanova. A study on the variability of minicolumnar width in the brains of patients with autism. Biological psychiatry 2004; 55(8), 15S–16S.

Manuel F. Casanova, Leonie de Zeeuw, Andrew Switala, Pawel Kreczmanski, Harry W. M. Steinbusch, Helmut Heinsen, Christoph Schmitz. Lamination abnormalities in the prefrontal cortex of patients with schizophrenia. Biological psychiatry 2004; 55(8), 214S.

I.van Kooten, M.F.Casanova, A.E.Switala, H.van Engeland, H.Heinsen, H.W.M.Steinbusch, P.R.Hof, J.Pickett, C.Schmitz. Neuronal size and number in the neocortex of autistic patients. Abstracts: Society for Neuroscience 2005 Nov 14; 31, §448.19.

M.F.Casanova, I.van Kooten, A.E.Switala, H.van Engeland, H.Heinsen, H.W.M.Steinbusch, P.R.Hof, L.C.Walker, C.Schmitz. Minicolumnar abnormalities in the neocortex of autistic patients. Abstracts: Society for Neuroscience 2005 Nov 14; 31, §448.20.

J.T.Trippe, A.E.Switala, G.D.Mower, M.F.Casanova. Invariance of minicolumnar structure during human prenatal and postnatal development. Abstracts: Society for Neuroscience 2005; 31, §480.22.

Manuel F. Casanova, Imke van Kooten, Andrew E. Switala, Herman van England, Helmut Heinsen, H.W.M. Steinbusch, Patrick R. Hof, Juan Trippe, Janet Stone, Christoph Schmitz. Minicolumnar width abnormalities in autism. Biological psychiatry 2006; 59(8), 19S.

Manuel F. Casanova, Imke van Kooten, Andrew E. Switala, Herman van England, Helmut Heinsen, H.W.M. Steinbusch, Patrick R. Hof, Juan Trippe, Janet Stone, Christoph Schmitz. Neuronal Size and Numbers in Autism. Biological psychiatry 2006; 59(8), 20S.

Manuel F. Casanova, Juan Trippe, Andrew Switala. A temporal continuity to the vertical organization of the human neocortex. Biological psychiatry 2006; 59(8), 110S.

Manuel F. Casanova, Jay Giedd, Judith M. Rumsey, Glenn Mannheim. A negative study on the gyrification index in patients with autism. Biological psychiatry 2006; 59(8), 110S.

Manuel F. Casanova, Imke Van Kooten, Andrew E. Switala, Herman Van Engeland, Helmut Heinsen, H.W.M. Steinbusch, Patrick Hof, Juan Trippe, Janet Stone, Christoph Schmitz. Abnormalities of cortical minicolumnar organization in the prefrontal lobes of autistic patients. Biological psychiatry 2006; 59(8), 119S.

R. N. Parthasarathy, M. F. Casanova, J. Giedd, J. M. Rumsey, G. Mannheim. A negative study on the gyrification index in patients with autism. Abstracts: Society for Neuroscience 2006; 32, §96.6.

M. F. Casanova, I. van Kooten, A. E. Switala, H. van England, H. Heinsen, H. W. Steinbusch, P. R. Hof, C. Schmitz. Abnormalities of cortical minicolumnar organization in the prefrontal lobes of autistic patients. Abstracts: Society for Neuroscience 2006; 32, §96.7.

R. S. Seelan, R. N. Parthasarathy, M. F. Casanova. Differential methylation of the gene encoding myo-inositol synthase in rat and human tissues: implications for autism. Abstracts: Society for Neuroscience 2006; 32, §96.13.

F.A. Crespo, J.A. Bouldin, G.R. Fernandez-Botrán, M.F. Casanova, C.R. Tillquist. A global survey of cytokine expression polymorphism in human populations. American journal of physical anthropology 2007; 132(S44), 92–93.

Ayman S. El-Baz, Aly Farag, Meghan Mott, Hossam Hassan, Rachid Fahmi, Andrew Switala, Manuel F. Casanova. Abnormalities of the gyral window in autism: a macroscopic correlate to a putative minicolumnopathy. IMFAR Program Booklet & Abstracts 2007 May; 6: 123–124.

Andrew E. Switala, Juan Trippe, Michael Fitzgerald, Manuel F. Casanova. Comparison of the minicolumnar morphometry of three distinguished neuroscientists and controls. IMFAR Program Booklet & Abstracts 2007 May; 6: 125.

Christopher Tillquist, Juan Trippe II, Andrew Switala, Manuel F. Casanova. Morphometric variability of minicolumns in the striate cortex of Homo sapiens, Macaca mulatta, and Pan troglodytes. IMFAR Program Booklet & Abstracts 2007 May; 6: 125.

Juan Trippe, Andrew E. Switala, Manuel F. Casanova. A temporal continuity to the vertical organization of the human neocortex. IMFAR Program Booklet & Abstracts 2007 May; 6: 126.

Manuel F Casanova, Imke van Kooten, Andrew E. Switala, Herman van Engeland, Helmut Heinsen, Harry W.M. Steinbusch, Patrick R. Hof, Christoph Schmitz. Abnormalities of cortical minicolumnar organization in the prefrontal lobes of autistic patients. IMFAR Program Booklet & Abstracts 2007 May; 6: 149.

M. C. Mott, M. Casanova, R. Fernandez-Botrán, L. Sears, C. Tillquist, F. Crespo. Cytokine polymorphisms and their role in autism: a maternal and child perspective. Abstracts: Society for Neuroscience 2007; 33, §58.20.

R. S. Seelan, J. Lakshmanan, M. F. Casanova, R. N. Parthasarathy. Differential methylation of the gene encoding myo-inositol synthase in rat and human tissues: implications for autism. Abstracts: Society for Neuroscience 2007; 33, §163.2.

J. Lakshmanan, R. S. Seelan, M. F. Casanova, R. N. Parthasarathy. Role of phosphorylation in the regulation of inositol levels in the brain. Abstracts: Society for Neuroscience 2007; 33, §163.12.

M. F. Casanova, J. Trippe, II, C. R. Tillquist, A. E. Switala. Radial bias in structure of dolphin insular cortex likely reflects minicolumnar organization characteristic of mammalian isocortex. Abstracts: Society for Neuroscience 2007; 33, §347.6.

F. A. Crespo, R. Oberst, G. R. Fernandez-Botrán, M.F. Casanova, C.R. Tillquist. Cytokine expression polymorphism in European human populations. American journal of physical anthropology 2008; 135(S46), 83–84.

M. F. Casanova. Autism as a minicolumnopathy. IMFAR Program Booklet & Abstracts 2008 May; 7, §120.4.

M. F. Casanova, P. Narahari, A. S. El-Baz, E. A. Vanbogaert, A. E. Switala. Minicolumnar core width by lamina in brains of patients with autism. IMFAR Program Booklet & Abstracts 2009 May; 8, §105.12.

M. F. Casanova, A. S. El-Baz, M. C. Mott, G. B. Mannheim, H. Hassan, R. Fahmi, J. N. Giedd, J. M. Rumsey, A. E. Switala, A. A. Farag. Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy. IMFAR Program Booklet & Abstracts 2009 May; 8, §105.13.

E. M. Sokhadze, A. S. El-Baz, J. M. Baruth, A. Tasman, G. Mathai, L. Sears and M. F. Casanova. Electrocortical and behavioral outcomes of novel experimental trial of repetitive transcranial magnetic stimulation in autism. IMFAR Program Booklet & Abstracts 2009 May; 8, §112.43.

M. C. Mott, M. F. Casanova, G. R. Fernandez-Botrán, L. Sears, C. R. Tillquist, F. A. Crespo. Cytokine polymorphisms and their potential role in autism. IMFAR Program Booklet & Abstracts 2009 May; 8, §120.44.

M. F. Casanova, E. M. Sokhadze, L. Sears, J. M. Baruth Event-related potential study of the effects of repetitive transcranial magnetic stimulation on novelty processing in autism. IMFAR Program Booklet & Abstracts 2009 May; 8, §134.33.

Estate Sokhadze, Joshua Baruth, Ayman El-Baz, Rajesh Ramaswamy, Lonnie Sears, Manuel Casanova. Transcranial magnetic stimulation study of gamma frequency induction in response to illusory figures in patients with autism spectrum disorders. Journal of Neurotherapy 2009; 13(4): 271–272.

M. F. Casanova, A. S. El-Baz, A. E. Switala, E. L. Williams, D. L. Williams, N. J. Minshew, T. E. Conturo. Quantitative analysis of the shape of the corpus callosum in autism. IMFAR Program Booklet & Abstracts 2010 May 21; 9, §130.04.

J. M. Baruth, E. M. Sokhadze, L. L. Sears, M. F. Casanova. Sensory filtering abnormalities in autism spectrum disorder (ASD). IMFAR Program Booklet & Abstracts 2010 May 21; 9, §130.046.

M. C. Mott, M. F. Casanova, G. R. Fernandez-Botrán, L. Sears, C. R. Tillquist, F. Crespo. Transcriptional analysis of cytokines in the cerebral cortex of autistic patients. IMFAR Program Booklet & Abstracts 2010 May 22; 9, §136.109.

E. M. Sokhadze, J. M. Baruth, A. S. El-Baz, T. Horrell, A. Tasman, G. Mathai, L. L. Sears, M. Casanova. Effects of repetitive transcranial magnetic stimulation on behavior and functional cortical connectivity outcomes in autism. IMFAR Program Booklet & Abstracts 2010 May 22; 9, §136.047.

Estate Tato Sokhadze, Ayman El-Baz, Joshua Baruth, Allan Tasman, Grace Mathai, Lonnie Sears, Manuel Casanova. Repetitive TMS affects EEG gamma and ERP during perceptual processing in autism. Applied Psychophysiology and Biofeedback 2010 June; 35(2): 178–179.

Manuel F. Casanova, Ayman S. El-Baz, Andrew E. Switala, Emily L. Williams, Diane L. Williams, Nancy J. Minshew, Thomas E. Conturo. Quantitative analysis of the shape of the corpus callosum in autism. Scientific Proceedings: AACAP 57th Annual Meeting 2010 October 27; 57: NRPOSTER-1.38.

Meghan C. Mott, Manuel F. Casanova, Rafael Fernandez-Botrán, Lonnie L. Sears, Christopher R. Tillquist, Fabián A. Crespo. Transcriptional analysis of cytokines in the cerebral cortex of autistic patients. Scientific Proceedings: AACAP 57th Annual Meeting 2010 October 27; 57: NRPOSTER-1.39.

Estate M. Sokhadze, Joshua M. Baruth, Ayman S. El-Baz, Timothy J. Horrell, Guela Sokhadze, Thomas M. Carroll, Allan Tasman, Lonnie L. Sears, Manuel F. Casanova. Impaired error monitoring and correction function in autism. Scientific Proceedings: AACAP 57th Annual Meeting 2010 October 27; 57: NRPOSTER-1.40.

Manuel F. Casanova, Ayman S. El-Baz, Ahmed Elnakib, Jay N. Giedd, Judith M. Rumsey, Emily L. Williams, Andrew E. Switala. Corpus callosum shape analysis with application to dyslexia. Scientific Proceedings: AACAP 57th Annual Meeting 2010 October 28; 57: NRPOSTER-2.25.

L. L. Sears, E. M. Sokhadze, J. M. Baruth, M. F. Casanova. Combination of repetitive transcranial magnetic stimulation and neurofeedback for treatment of autism: a case study. IMFAR Program Booklet & Abstracts 2011 May 12; 10, §105.095.

M. C. Mott, F. Crespo, G. R. Fernandez, L. L. Sears, P. G. Williams, M. F. Casanova. Evaluation of cytokine expression in cerebral cortex and blood plasma of autistic patients. IMFAR Program Booklet & Abstracts 2011 May 12; 10, §110.002.

J. M. Baruth, E. M. Sokhadze, L. L. Sears, M. F. Casanova. Transcranial magnetic stimulation modulates P300 indices of selective attention in autism. IMFAR Program Booklet & Abstracts 2011 May 12; 10, §110.060.

M. F. Casanova, J. M. Baruth, A. S. El-Baz, L. L. Sears, E. M. Sokhadze. Low-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Evoked-Gamma Frequency Oscillations In Autism Spectrum Disorder (ASD). IMFAR Program Booklet & Abstracts 2011 May 12; 10, §110.076.

G. Sokhadze, A. S. El-Baz, L. L. Sears, J. M. Baruth, E. M. Sokhadze, M. F. Casanova. ERP measures of facial negative emotional expression recognition in autism and ADHD. IMFAR Program Booklet & Abstracts 2011 May 12; 10, §110.079.

B. A. Dombroski, A. E. Switala, A. S. El-Baz, M. F. Casanova. MRI analysis of gyral window in normal brain development and its implications for studies in autism. IMFAR Program Booklet & Abstracts 2011 May 13; 10, §116.034.

E. M. Sokhadze, J. M. Baruth, L. L. Sears, G. Sokhadze, A. S. El-Baz, M. F. Casanova. Electrophysiological assessment of attention regulation in adhd, autism spectrum disorder, and typical children. IMFAR Program Booklet & Abstracts 2011 May 14; 10, §134.017.

Guela Sokhadze, Estate Sokhadze, Ayman El-Baz, Lonnie Sears, Joshua Baruth, Manuel Casanova. ERP measures of facial emotional prosody recognition in autism and ADHD. Applied Psychophysiology and Biofeedback 2011 September; 36(3): 223–224.

Joshua Baruth, Manuel Casanova, Guela Sokhadze, Lonnie Sears, Estate Sokhadze. Transcranial magnetic stimulation modulates cognitive potentials in autism. Applied Psychophysiology and Biofeedback 2011 September; 36(3): 224.

Guela Sokhadze, Melvin Kaplan, Stephen M Edelson, Estate M Sokhadze, Joshua Baruth, Ayman S El-Baz, Marie K Hensley, Manuel F Casanova. Modulatory effects of ambient prism lenses on spatial attention in autism: an event-related potential study. Journal of Neurotherapy 2011 December; 15(4): 413–415.

Joshua Baruth, Manuel Casanova, Lonnie Sears, Estate Sokhadze. Transcranial magnetic stimulation (rTMS) modulates selective attention and executive functioning in autism. Journal of Neurotherapy 2011 December; 15(4): 431–432.

Estate Sokhadze, Joshua Baruth, Lonnie Sears, Guela E Sokhadze, Ayman El-Baz, Marie Hensley, Allan Tasman, Manuel F Casanova. Event-related potential study of attention regulation in ADHD, autism spectrum disorder, and typical children. Journal of Neurotherapy 2011 December; 15(4): 443–445.

Estate Sokhadze, Joshua Baruth, Lonnie Sears, Guela E Sokhadze, Ayman El-Baz, Marie Hensley, Eric Gross, Allan Tasman, Manuel F Casanova. Neuromodulation using rTMS improves error monitoring and correction function in autism spectrum disorders. Journal of Neurotherapy 2011 December; 15(4): 445–447.

Estate M. Sokhadze, Melvin Kaplan, Stephen M. Edelson, Barbara Kotsamanidis, Marie K. Hensley, Guela E. Sokhadze, Brynn Dombroski, Manuel F. Casanova. Ambient prism lenses affect autonomic reactivity and attention to audio-visual stimuli in autism. Psychophysiology 2012 September 19; 49(S1): S40.

Estate (Tato) M Sokhadze, Lonnie L Sears, Guela E Sokhadze, Stephen M Edelson, Allan Tasman, Manuel F Casanova. Motor response preparation deficits in a cued spatial attention task in autism. Psychophysiology 2014 September 10; 51(S1):S16.

Marie K Hensley, Ayman S El-Baz, Estate (Tato) M Sokhadze, Lonnie L Sears, Manuel F Casanova. Effects of 18 session TMS therapy on gamma coherence in autism. Psychophysiology 2014 September 10; 51(S1):S16.

Research support

Sponsor Project Period Role
National Institute of Mental Health Z01 MH-2394 Magnetic resonance imaging (MRI) studies 1985-10-01 / 1988-09-30 Co-investigator (PI: Daniel R. Weinberger)
National Institute of Mental Health Z01 MH-2399 Postmortem brain tissue examination in neuropsychiatric disorders 1985-10-01 / 1990-09-30 Co-investigator (PI: Joel E. Kleinman)
National Institute of Mental Health Z01 MH-2351 Pathology of selected central nervous system degenerative disorders 1986-10-01 / 1987-09-30 PI
Eunice Kennedy Shriver National Institute of Child Health & Human Development P01 HD-24234 Rett syndrome—program project 1988-05-01 / 1993-04-30 Co-investigator (PD: Alan Kenneth Percy)
Theodore and Vada Stanley Foundation Research award, Electron microscopic morphometric study of glio-synaptic relationships in autopsy brains of patients with schizophrenia 1992 Sponsor (PI: Natalya Uranova)
Department of Veterans Affairs VA merit review, Morphological correlates of dementia in schizophrenia 1994 / 1998 PI
National Center for Complementary & Alternative Medicine R01 AT-147 Oxidative cell injury: first episode psychotic patients 1999-09-30 / 2003-08-31 Co-investigator (PI: Sahebarao P. Mahadik)
Theodore and Vada Stanley Foundation Research award, Increased interneuronal space in the minicolumns of major depression and bipolar disorder brains 2001 / 2003 PI
National Institute of Mental Health R01 MH-61606 Normal human and schizophrenic brain 2001-09-25 / 2005-08-31 PI
Medical College of Georgia Combined Intramural Grants Program, Modular abnormalities of brain organization in autism 2002 / 2003 PI
National Institute of Mental Health R01 MH-62654 Reduced interneuronal space in schizophrenic brains 2002-06-04 / 2006-05-31 PI
National Alliance for Autism Research PCF 04-0909 MRI correlates of minicolumnar pathology in autism 2003-11-01 / 2005-10-31 PI
National Institutes of Health R01 MH-69991 Modular abnormalities of brain organization in autism 2004-07-01 / 2008-05-31 PI
Department of Veterans Affairs VA merit review, Mood stabilizing medications and the inositol signaling system 2005-04-01 / 2009-03-31 co-I
National Institute of Environmental Health Sciences P30 ES-14443 Center for Environmental Genomics and Integrative Biology (CEGIB) 2007-06-04 / 2011-03-31 Board member (PD: Kenneth S. Ramos)
Autism Speaks Pre-doctoral metored fellowship, Electrocortical study of cognitive and perceptual processing deficits in autism 2008-08-01 / 2010-07-31 Mentor
Autism Speaks Basic & clinical research grant, Cytokine polymorphisms and their role in autism 2008-10-01 / 2010-09-30 Collaborative consultant
National Institute of Mental Health R01 MH-86784 Building a selective inhibitory control tone in autism: an rTMS study 2009-07-01 / 2013-05-31 PI
Eunice Kennedy Shriver National Institute of Child Health & Human Development R01 HD-65279 Gross morphological correlates to the minicolumnopathy of autism 2009-09-30 / 2011-08-31 PI
Wallace H. Coulter Foundation Coulter Translational Research Partnership Award: A novel image-based diagnostic system for the accurate diagnosis of autism 2012 / 2014 co-PI

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Contact persons for this Web site are Manuel F. Casanova (principal investigator) and Andrew E. Switala (administrator).