Portrait

Manuel F. Casanova, M.D.

Gottfried and Gisela Kolb Endowed Chair in Psychiatry

Vice Chair for Research

Department of Psychiatry
500 S Preston St Bldg 55A Ste 217
Louisville, Kentucky 40292-1702
Tel: 502-852-4077
Fax: 502-813-6665

E-mail: m zero c a s a zero two at louisville dot edu

Biosketch

Dr. Manuel Casanova made his residency training in neurology and then spent 3 years doing a fellowship in neuropathology at The Johns Hopkins Hospital. During his stay at the Johns Hopkins Hospital, Dr. Casanova was in-charge of Pediatric Neuropathology, a fact which kindled his interest in developmental disorders of the brain. His clinical experience was enhanced by appointments as either a consultant or staff neuropathologist at Sinai Hospital (Maryland), the North Charles Hospital and the D.C. General Hospital. He spent several years as Deputy Medical Examiner for Washington, D.C., where he gained valuable experience in the post-mortem examination of Sudden Infant Death Syndrome and child abuse. His expertise in the field was recognized by honorary appointments as a Scientific Expert for the Armed Forces Institute of Pathology (AFIP) and as a Professorial Lecturer for the Department of Forensic Science at George Washington University. Dr. Casanova spent 8 years helping to establish 2 of the most successful brain banks in this country: The Johns Hopkins Brain Resource Center (3 years) and the Brain Bank Unit of the Clinical Brains Disorders Branch at the National Institutes of Mental Health (5 years). Dr. Casanova did training in psychiatry at the National Institutes of Mental Health under the tutelage of Drs. Richard Wyatt, Danny Weinberger, and Joel Kleinman. He retired as a Major in the US Army Reserves and later on as a Lt. Commander in the Public Health Service. He joined the Medical College of Georgia as a full Professor in 1991 and came to the University of Louisville in 2003 as the Gottfried and Gisela Kolb Endowed Chair in Psychiatry.

See also this Wikipedia entry.

Research interests

Dr. Casanova has had over twenty years of experience in the neurosciences. Although trained in the classical methods of neurology and neuropathology his interest has gradually shifted towards the study of abnormalities of cortical circuitry. His research has focused on the cell minicolumn, a vertical conglomerate of 80 to 100 neurons having a common latency of response to stimulation. Using computerized imaging analysis he has established the anatomical validity of the cell minicolumn. His earlier work has reported interhemispheric differences in the morphometry of minicolumns that could provide for the speciation of hominids. Localized in Brodmann area 22—part of Wernicke’s language region—the morphometric difference may play a role both in the development of language and in its disorders. His most recent studies have looked for the presence of abnormalities of minicolumnar organization and lateralization in the brains of patients who exhibit language disturbances, including autism, Asperger’s syndrome, and dyslexia. He has summarized his work on minicolumns and provided an overview of the field in recent reviews of the literature appearing in Brain and Brain, Behavior and Evolution.

Citations/appearances in popular media

Recent publications

This list only includes publications from the past five years. For earlier work, see the full curriculum vitae. Links to online content are provided when possible, but full text access often requires a subscription to the relevant journal. Additional content can be found on the Laboratory of Neuropsychiatry publications page.

In press

Manuel F. Casanova. The neuropathology of autism. In: S. Hossein Fatemi, editor. The molecular basis of autism, chapter 8. New York: Springer; 2015 February 14. Mario Manto, series editor. Contemporary clinical neuroscience.

Emily L. Williams, Manuel F. Casanova. Ultrasound and autism: how disrupted redox homeostasis and transient membrane porosity confer risk. In: Anna Dietrich-Muszalska, Ved Chauhan, Sylvain Gagnon, editors. Studies on psychiatric disorders, ch. 18. New York: Humana Press; 2015 January 17. Donald Armstrong, series editor. Oxidative stress in applied basic research and clinical practice.

Jeffrey J. Hutsler, Manuel F. Casanova. Cortical construction in autism spectrum disorder: columns, connectivity and the subplate. Neuropathology and applied neurobiology 2014; in press.

Published

Estate M. Sokhadze, Ayman S. El-Baz, Allan Tasman, Lonnie L. Sears, Yao Wang, Eva V. Lamina, Manuel F. Casanova. Neuromodulation integrating rTMS and neurofeedback for the treatment of autism spectrum disorder: an exploratory study. Applied psychophysiology and biofeedback 2014 December; 39(3–4): 237–257.

Emily L. Casanova, Manuel F. Casanova. Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism. Frontiers in cellular neuroscience 2014 November 19; 8: 397.

Manuel Fernando Casanova, Marie K. Hensley, Estate M. Sokhadze, Ayman S. El-Baz, Yao Wang, Xiaoli Li, Lonnie Sears. Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder. Frontiers in human neuroscience 2014 October 21; 8: 851.

Ahmed Elnakib, Ahmed Soliman, Matthew Nitzken, Manuel F. Casanova, Georgy Gimel’farb, Ayman El-Baz. Magnetic resonance imaging findings for dyslexia: a review. Journal of biomedical nanotechnology 2014 October; 10(10): 2778–2805.

Мануэл Ф. Казанова. Модульное устройство коры головного мозга: микроколонки и их патологии. Сибирский вестник специального образования 2014 August 26; 1(13): 9–13.

Estate M. Sokhadze, Ayman S. El-Baz, Lonnie L. Sears, Ioan Opris, Manuel F. Casanova. rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism. Frontiers in systems neuroscience 2014 July 9; 8: 134.

Manuel F. Casanova, Estate M. Sokhadze. Transcranial magnetic stimulation: application in autism treatment. In: Valerie W. Hu, editor. Frontiers in autism research: new horizons for diagnosis and treatment, 583–606. Hackensack: World Scientific Publishing; 2014 July 7.

Matthew J. Nitzken, Manuel F. Casanova, Georgy Gimel’farb, Tamer Inanc, Jacek M. Zurada, Ayman El-Baz. Shape analysis of the human brain: a brief survey. IEEE journal of biomedical and health informatics 2014 July; 18(4): 1337–1354.

Muthusamy Thangavel, Ratnam S. Seelan, Jaganathan Lakshmanan, Robert E. Vadnal, John I. Stagner, Latha K. Parthasarathy, Manuel F. Casanova, Rifaat Shody El-Mallakh, Ranga N. Parthasarathy. Proteomic analysis of rat prefrontal cortex after chronic valproate treatment. Journal of neuroscience research 2014 July; 92(7): 927–936.

Ioan Opris, Manuel F. Casanova. Prefrontal cortical minicolumn: from executive control to disrupted cognitive processing. Brain 2014 July; 137(7): 1863–1875.

Manuel F. Casanova. Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias. Medical hypotheses 2014 July; 83(1): 32–38.

F Zeidán-Chuliá, B-H Neves de Oliveira, A B Salmina, M F Casanova, D Pens Gelain, A Verkhratsky, J C Fonseca Moreira. Altered expression of Alzheimer’s disease related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy. Cell death & disease 2014 May 22; 5: e1250.

Mahmoud Mostapha, Amir Alansary, Ahmed Soliman, Fahmi Khalifa, Matthew Nitzken, Rasha Khodeir, Manuel F. Casanova, Ayman El-Baz. Atlas-based approach for the segmentation of infant DTI MR brain image. IEEE international symposium on biomedical imaging: From nano to macro 2014 Apr 29; 11: 1255–1258.

Brynn A. Dombroski, Matthew J. Nitzken, Ahmed A. Elnakib, Fahmi Khalifa, Andrew E. Switala, Ayman S. El-Baz, Manuel F. Casanova. Cortical surface complexity in a population-based normative sample. Translational neuroscience 2014 March; 5(1): 17–24.

Manuel F. Casanova. The neuropathology of autism. In: Fred R. Volkmar, Rhea Paul, Sally J. Rogers, Kevin A. Pelphrey, editors. Handbook of autism and pervasive developmental disorders, fourth edition, 497–531. New York: Wiley; 2014 March 3.

Manuel F. Casanova, Brynn Dombroski, Andrew E. Switala. Imaging and the corpus callosum in patients with autism. In: Vinood B. Patel, Victor R. Preedy, Colin R. Martin, editors. The comprehensive guide to autism, 947–962. Berlin: Springer; 2013 October 30.

Steven A. Chance, Manuel F. Casanova. Auditory cortex asymmetry and language processing in schizophrenia. In: Paolo Brambilla, Andrea Marini, editors. Brain evolution, language, and psychopathology in schizophrenia, 53–72. London: Psychology Press; 2013 October 23. Explorations in mental health.

Manuel F. Casanova, Ayman S. El-Baz, Shweta S. Kamat, Brynn A. Dombroski, Fahmi Khalifa, Ahmed Elnakib, Ahmed Soliman, Anita Allison-McNutt, Andrew E. Switala. Focal cortical dysplasias in autism spectrum disorders. Acta neuropathologica communications 2013 October 11; 1: 67.

Richard E. Frye, Daniel Rossignol, Manuel F. Casanova, Gregory L. Brown, Victoria Martin, Stephen Edelson, Robert Coben, Jeffrey Lewine, John C. Slattery, Chrystal Lau, Paul Hardy, S. Hossein Fatemi, Timothy D. Folsom, Derrick MacFabe, James B. Adams. A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel. Frontiers in public health 2013 September 13; 1: 31.

Estate M. Sokhadze, Manuel F. Casanova, Joshua Baruth. Transcranial magnetic stimulation in autism spectrum disorders. Lucia Alba-Ferrara, editor. Transcranial magnetic stimulation: methods, clinical uses and effects on the brain, 219–231. Hauppauge: Nova Science Publishers; 2013 August 22.

Emily L. Williams, Manuel F. Casanova, Andrew E. Switala, Hong Li, Mengsheng Qiu. Transposable elements occur more frequently in autism-risk genes: implications for the role of genomic instability in autism. Translational neuroscience 2013 June; 4(2): 172–202.

R. N. Parthasarathy, J. Lakshmanan, M. Thangavel, R. S. Seelan, J. I. Stagner, A. J. Janckila, R. E. Vadnal, M. F. Casanova, L. K. Parthasarathy. Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein. Molecular and cellular biochemistry 2013 June; 378(1–2): 83–89.

Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism. New York: Springer; 2013 May 31.

Manuel F. Casanova, Paul H. Patterson, Eric London. Introduction to neuropathology. In: Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism, 1–26. New York: Springer; 2013 May 31.

Manuel F. Casanova, Jane Pickett. The neuropathology of autism. In: Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism, 27–43. New York: Springer; 2013 May 31.

Estate M. Sokhadze, Joshua Baruth, Allan Tasman, Manuel F. Casanova. Event-related potential studies of cognitive processing abnormalities in autism. In: Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism, 61–86. New York: Springer; 2013 May 31.

Manuel F. Casanova, Joshua Baruth, Ayman S. El-Baz, Guela E. Sokhadze, Marie Hensley, Estate M. Sokhadze. Evoked and induced gamma-frequency oscillations in autism. In: Manuel F. Casanova, Ayman S. El-Baz, Jasjit S. Suri, editors. Imaging the brain in autism, 87–106. New York: Springer; 2013 May 31.

Manuel F. Casanova. Neural mechanisms in autism. In: Fred Volkmar, ed. Encyclopedia of autism spectrum disorders, 1994–2007. Heidelberg: Springer; 2013 April 2.

Emily L. Williams, Manuel F. Casanova. Reassessment of teratogenic risk from antenatal ultrasound. Translational neuroscience 2013 March; 4(1): 81–87.

Richard E. Frye, Manuel Casanova, Gregory L. Brown, Victoria Martin, Stephen Edelson, Robert Coben, Jeffrey Lewine, Daniel Rossignol, Derrick MacFabe, John Slattery, James B. Adams. A consensus statement from the Elias Tembenis Seizures Think Tanks. Autism science digest 2012 December; 5: 4–10.

Meghan C. Mott, Rafael Fernandez-Botrán, Manuel F. Casanova. Neuroinflammation in the pathogenesis of Autism Spectrum Disorders: converging evidence for systemic and central nervous system immune interaction. In: Carmelina Gemma, editor. Neuroinflammation: pathogenesis, mechanisms and management, 149–179. New York: Nova Biomedical Books; 2012 November 30. Neuroscience research progress

Ahmed Elnakib, Matthew Nitzken, Manuel Casanova, HeYeon Park, Georgy Gimel’farb, Ayman El-Baz. Quantification of age-related brain cortex change using 3D shape analysis. International Conference on Pattern Recognition 2012 November 12; 21: 41–44.

Manuel F. Casanova. The minicolumnopathy of autism. In: Joseph D. Buxbaum, Patrick R. Hof, editors. The neuroscience of autism spectrum disorders, 327–334. Amsterdam: Academic Press; 2012 November 5.

Guela E. Sokhadze, Stephen M. Edelson, Manuel F. Casanova. Visual spatial attention event-related potential measures in autism. NeuroConnections 2012; Fall: 23–24.

Meghan C. Mott, Rafael Fernandez-Botrán, Manuel F. Casanova. Neuroinflammation in the pathogenesis of Autism Spectrum Disorders: converging evidence for systemic and central nervous system immune interaction. In: Owen B. Williams, Garet I. Wilson, editors. Advances in brain research, chapter 11. New York: Nova Biomedical Books; 2012 September 30. Neuroscience research progress

Emily L. Williams, Manuel F. Casanova. Hyperlexia and dyslexia in autism: hitting a moving target. Journal of special education and rehabilitation 2012 September 14; 13(3–4): 39–54.

Deepak P. Srivastava, Kelly A. Jones, Kevin M. Woolfrey, Jeffrey Burgdorf, Theron A. Russell, Abigail Kalmbach, Hyerin Lee, Connie Yang, Mazdak M. Bradberry, David Wokosin, Joseph R. Moskal, Manuel F. Casanova, Jack Waters, Peter Penzes. Social, communication, and cortical structural impairments in Epac2-deficient mice. The journal of neuroscience 2012 August 22; 32(34): 11864–11878.

Robert C. Pennington, Karla Conn Welch, Estate Sokhadze, Ayman El-Baz, Aly Farag, Patricia G. Williams, Manuel F. Casanova. Crossing the divide: collaborative efforts towards innovative treatments at the University of Louisville Autism Center. In: Ken Siri, Tony Lyons, editors. Cutting-edge therapies for autism, fully updated edition, 161–164. New York: Skyhorse Publishing; 2012 July 15.

Joshua M. Baruth, Estate Sokhadze, Ayman El-Baz, Grace Mathai, Lonnie Sears, Manuel F. Casanova. Transcranial magnetic stimulation. In: Ken Siri, Tony Lyons, editors. Cutting-edge therapies for autism, fully updated edition, 143–152. New York: Skyhorse Publishing; 2012 July 15.

Ahmed Elnakib, Manuel F. Casanova, Georgy Gimel’farb, Andrew E. Switala, Ayman El-Baz. Dyslexia diagnostics by 3-D shape analysis of the corpus callosum. IEEE transactions on information technology in biomedicine 2012 July; 16(4): 700–708

Estate (Tato) Sokhadze, Guela Sokhadze, Manuel Casanova. Neuromodulation using transcranial DC stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) as a translational neuroscience approach to treat autism. NeuroConnections 2012; Summer: 16–18.

Manuel F. Casanova, Joshua M. Baruth, Ayman El-Baz, Allan Tasman, Lonnie Sears, Estate Sokhadze. Repetitive transcranial magnetic stimulation (rTMS) modulates event-related potential (ERP) indices of attention in autism. Translational neuroscience 2012 June; 3(2): 170–180.

Eric Gross, Ayman S. El-Baz, Guela E. Sokhadze, Lonnie Sears, Manuel F. Casanova, Estate M. Sokhadze. Induced EEG gamma oscillation alignment improves differentiation between autism and ADHD group responses in a facial categorization task. Journal of Neurotheraphy 2012 June; 16(2): 78–91.

Estate Sokhadze, Joshua M. Baruth, Lonnie Sears, Guela E. Sokhadze, Ayman S. El-Baz, Manuel F. Casanova. Prefrontal neuromodulation using rTMS improves error monitoring and correction function in autism. Applied Psychophysiology & Biofeedback 2012 June; 37(2): 91–102.

Mostafa Abdelrahman, Asem Ali, Ahmed Farag, Manuel F. Casanova, Aly Farag. New approach for classification of autistic vs. typically developing brain using white matter volumes. Computer and robot vision 2012 May 28; 9: 284–289.

Мануэль Ф. Касанова, Меган Мотт, Тато М. Сохадзе. Невропатология аутизма: обзор современной литературы. Сибирский вестник специального образования 2012 April; 6(2): 54–69.

Emily L. Williams, Ayman El-Baz, Matthew Nitzken, Andrew E. Switala, Manuel F. Casanova. Spherical harmonic analysis of cortical complexity in autism and dyslexia. Translational Neuroscience 2012 March; 3(1): 36–40.

Estate M. Sokhadze, Joshua M. Baruth, Lonnie Sears, Guela E. Sokhadze, Ayman S. El-Baz, Emily L. Williams, Robert Klapheke, Manuel F. Casanova. Event-related potential study of attention regulation during illusory figure categorization task in ADHD, autism spectrum disorder, and typical children. Journal of Neurotherapy 2012 March, 16(1): 12–31.

Ahmed Elnakib, Manuel F. Casanova, Georgy Gimel’farb, Ayman El-Baz. Autism diagnostics by 3D shape analysis of the corpus callosum. In: Kenji Suzuki, editor. Machine learning in computer-aided diagnosis: medical imaging intelligence and analysis, 315–335. Hershey: Medical Information Science Reference; 2012 January 31.

Manuel F. Casanova, Ayman El-Baz, Andrew E. Switala. Laws of conservation as related to brain growth, aging, and evolution: symmetry of the minicolumn. Frontiers in Neuroanatomy 2011 December 26, 5: 66.

Ayman El-Baz, Ahmed Elnakib, Manuel F. Casanova, Georgy Gimel’farb, Andrew E. Switala, Desha Jordan, Sabrina Rainey. Accurate automated detection of autism related corpus callosum abnormalities. Journal of Medical Systems 2011 October; 35(5): 929–939.

Vladimír Blažek, Jaroslav Brůžek, Manuel F. Casanova. Plausible mechanisms for brain structural and size changes in human evolution. Collegium Antropologicum 2011 September; 35(3): 949–955.

M. Nitzken, M. Casanova, G. Gimel’farb, A. Elnakib, F. Khalifa, A. Switala, and A. El-Baz. 3D shape analysis of the brain cortex with application to dyslexia. IEEE International Conference on Image Processing 2011 September 11; 18: 2657–2660.

Manuel F. Casanova, Sergio E. Starkstein, Kurt A. Jellinger. Clinicopathological correlates of behavioral and psychological symptoms of dementia. Acta Neuropathologica 2011 August; 122(2): 117–135.

Brynn A. Dombroski, Andrew E. Switala, Ayman S. El-Baz, Manuel F. Casanova. Gyral window mapping of typical cortical folding using MRI. Translational Neuroscience 2011 June; 2(2): 142–147.

Emily L. Williams, Manuel F. Casanova. Above genetics: lessons from cerebral development in autism. Translational Neuroscience 2011 June; 2(2): 106–120.

Matthew Nitzken, Manuel F. Casanova, Fahmi Khalifa, Guela Sokhadze, Ayman El-Baz. Shape-based detection of cortex variability for more accurate discrimination between autistic and normal brains. In: Ayman S. El-Baz, Rajendra Acharya U, Andrew F. Laine, Jasjit S. Suri, eds. Multi modality state-of-the-art medical image segmentation and registration methodologies, 161–185. New York: Springer; 2011 May 12.

Manuel F. Casanova, Estate Sokhadze, Ayman El-Baz, Joshua Baruth, Grace Mathai, Lonnie Sears. Research at the University of Louisville Autism Center. In: Ken Siri, Tony Lyons, eds. Cutting-edge therapies for autism: 2011–2012, 425–429. New York: Skyhorse Publishing; 2011 April 1.

Joshua Baruth, Estate Sokhadze, Ayman El-Baz, Grace Mathai, Lonnie Sears, Manuel F. Casanova. Transcranial magnetic stimulation as a treatment for autism. In: Ken Siri, Tony Lyons, eds. Cutting-edge therapies for autism: 2011–2012, 402–411. New York: Skyhorse Publishing; 2011 April 1.

Emily L. Williams, Manuel F. Casanova. Prenatal ultrasound: it’s not just a photograph. Autism Science Digest 2011 April; 1(1): 58–60.

Joshua M. Baruth, Emily L. Williams, Estate Sokhadze, Ayman El-Baz, Manuel F. Casanova. Beneficial effects of repetitive transcranial magnetic stimulation (rTMS) on behavioral outcome measures in autism spectrum disorder. Autism Science Digest 2011 April; 1(1): 52–57.

M. Nitzken, M. F. Casanova, G. Gimel’farb, A. Elnakib, F. Khalifa, A. Switala, A. El-Baz. 3D shape analysis of the brain cortex with application to autism. IEEE international symposium on biomedical imaging: From nano to macro 2011 Mar 30; 8: 1847–1850.

A. Elnakib, M. F. Casanova, G. Gimel’farb, A. E. Switala, A. El-Baz. Autism diagnostics by centerline-based shape analysis of the corpus callosum. IEEE international symposium on biomedical imaging: From nano to macro. 2011 Mar 30; 8: 1843–1846.

Manuel F. Casanova, Ayman El-Baz, Ahmed Elnakib, Andrew E. Switala, Emily L. Williams, Diane L. Williams, Nancy J. Minshew, Thomas E. Conturo. Quantitative analysis of the shape of the corpus callosum in patients with autism and comparison individuals. Autism 2011 March; 15(2): 223–238.

Ratnam S. Seelan, M. Michele Pisano, Robert M. Greene, Manuel F. Casanova, Ranga N. Parthasarathy. Differential methylation of the gene encoding myo-inositol 3-phosphate synthase (Isyna1) in rat tissues. Epigenomics 2011 February; 3(1): 111–124.

Ahmed Farag, Shireen Elhabian, Mostafa Abdelrahman, James Graham, Aly Farag, Dongqing Chen, Manuel F. Casanova. Surface modeling of the corpus callosum from MRI scans. In: George Bebis, Richard Boyle, Bahram Parvin, Darko Koracin, Ronald Chung, Riad Hammoud, Muhammad Hussain, Tan Kar-Han, Roger Crawfis, Daniel Thalmann, David Kao, Lisa Avila, eds. Advances in visual computing: 6th International Symposium, ISVC 2010, Las Vegas, NV, USA, November 29–December 1, 2010, proceedings, part III. Lecture Notes in Computer Science 2010 December 13; 6455: 9–18.

Emily L. Williams, Manuel F. Casanova. Autism or autisms? Finding the lowest common denominator. Boletín de la Asociación Médica de Puerto Rico 2010 October; 102(4): 17–24.

Ahmed Elnakib, Ayman El-Baz, Manuel F. Casanova, Georgy Gimel’farb, Andrew E. Switala. Image-based detection of corpus callosum variability for more accurate discrimination between autistic and normal brains. IEEE International Conference on Image Processing 2010 September 26; 17: 4337–4340.

Ahmed Farag, Shireen Elhabian, Mostafa Abdelrahman, James Graham, Aly Farag, Dongqing Chen, Manuel F. Casanova. Shape modeling of the corpus callosum. Proceedings of the International Conference of the IEEE Engineering in Medicine and Biology Society 2010 September 3; 32: 4288–4291.

Ahmed Elnakib, Ayman El-Baz, Manuel F. Casanova, Andrew E. Switala. Dyslexia diagnostics by centerline-based shape analysis of the corpus callosum. Proceedings of the International Conference on Pattern Recognition 2010 Aug 23; 20: 261–264.

Joshua M. Baruth, Manuel F. Casanova, Ayman El-Baz, Tim Horrell, Grace Mathai, Lonnie Sears, Estate Sokhadze. Low-frequency repetitive transcranial magnetic stimulation modulates evoked-gamma frequency oscillations in autism spectrum disorder. Journal of Neurotherapy 2010 July; 14(3): 179–194.

E. L. Williams, M. F. Casanova. Potential teratogenic effects of ultrasound on corticogenesis: implications for autism. Medical Hypotheses 2010 Jul; 75(1): 53–58.

Joshua M. Baruth, Manuel F. Casanova, Lonnie Sears, Estate Sokhadze. Early-stage visual processing abnormalities in high-functioning autism spectrum disorder (ASD). Translational Neuroscience 2010 Jun; 1(2): 177–187.

Manuel F. Casanova, Ayman El-Baz, Ahmed Elnakib, Jay Giedd, Judith M. Rumsey, Emily L. Williams, Andrew E. Switala. Corpus callosum shape analysis with application to dyslexia. Translational Neuroscience 2010 Jun; 1(2): 124–130.

Estate Sokhadze, Joshua Baruth, Allan Tasman, Mehreen Mansoor, Rajesh Ramaswamy, Lonnie Sears, Grace Mathai, Ayman El-Baz, Manuel F. Casanova. Low-frequency repetitive transcranial magnetic stimulation (rTMS) affects event-related potential measures of novelty processing in autism. Applied Psychophysiology and Biofeedback 2010 Jun; 35(2): 147–161.

Manuel F. Casanova. The role of the entorhinal cortex in paraphrenia. Current Psychiatry Reports 2010 Jun; 12(3): 202–207.

Manuel F. Casanova. The pathology of paraphrenia. Current Psychiatry Reports 2010 Jun; 12(3): 196–201.

Estate Sokhadze, Joshua Baruth, Ayman El-Baz, Timothy Horrell, Guela Sokhadze, Thomas Carroll, Allan Tasman, Lonnie Sears, Manuel F. Casanova. Impaired error monitoring and correction function in autism. Journal of Neurotherapy 2010 May; 14(2): 79-95.

Ahmed Elnakib, Ayman El-Baz, Manuel F. Casanova, Georgy Gimel’farb, Andrew E. Switala. Image-based detection of corpus callosum variability for more accurate discrimination between dyslexic and normal brains. IEEE international symposium on biomedical imaging: From nano to macro. 2010 Apr 14; 7: 109–112.

Manuel Casanova, Estate Sokhadze, Ayman El-Baz, Joshua Baruth, Grace Mathai, Lonnie Sears. Research at the University of Louisville Autism Center. In: Ken Siri, Tony Lyons, eds. Cutting-edge therapies for autism: 2010–2011, 410–413. New York: Skyhorse Publishing; 2010 Apr 1.

Joshua Baruth, Estate Sokhadze, Ayman El-Baz, Grace Mathai, Lonnie Sears, Manuel F. Casanova. Transcranial magnetic stimulation. In: Ken Siri, Tony Lyons, eds. Cutting-edge therapies for autism: 2010–2011, 388–397. New York: Skyhorse Publishing; 2010 Apr 1.

Manuel F. Casanova. Cortical organization: anatomical findings based on systems theory. Translational Neuroscience 2010 March; 1(1): 62–71.

Manuel F. Casanova, Juan Trippe II, Christopher R. Tillquist, Andrew E. Switala. Radial structure of dolphin insula: dolphin insula reflects minicolumnar organization of mammalian isocortex. Translational Neuroscience 2010 March; 1(1): 37–42.

Manuel F. Casanova, Ayman El-Baz, Eric Vanbogaert, Praveen Narahari, Andrew Switala. A topographic study of minicolumnar core width by lamina comparison between autistic subjects and controls: possible minicolumnar disruption due to an anatomical element in-common to multiple laminae. Brain Pathology 2010 Mar; 20(2): 451–458.

Manuel F. Casanova, Ayman S. El-Baz, Jay Giedd, Judith M. Rumsey, Andrew E. Switala. Increased white matter gyral depth in dyslexia: implications for corticocortical connectivity. Journal of Autism and Developmental Disorders 2010 January; 40(1): 21–29.

Emily L. Williams, Manuel F. Casanova. Autism and dyslexia: a spectrum of cognitive styles as defined by minicolumnar morphometry. Medical hypotheses 2010 Jan; 74(1): 59–62.

Manuel F. Casanova, Ayman S. El-Baz, Eric Vanbogaert, Praveen Narahari, Juan Trippe. Minicolumnar width: comparison between supragranular and infragranular layers. Journal of Neuroscience Methods 2009 Oct 30; 184(1): 19–24.

Fabián Crespo, Rafael Fernandez-Botran, Christopher Tillquist, Lonnie Sears, Meghan Mott, Manuel Casanova. Cytokine polymorphisms in autism: their role in immune alterations. In: Abha Chauhan, Ved Chauhan, W. Ted Brown, eds. Autism: Oxidative stress, inflammation, and immune abnormalities, 315–324. Boca Raton: CRC Press; 2009 Oct 14.

Estate (Tato) Sokhadze, Joshua Baruth, Manuel Casanova. Neuropathological theories and EEG gamma oscillation abnormalities in autism. NeuroConnections 2009 Aug 11; 2009(Fall): 34–37.

Manuel F. Casanova. La esquizofrenia como condición neurológica debido a una falta en la lateralización del cerebro: observaciones micro- y macroscópicas. Revista de Neurología 2009 Aug 1; 49(3): 136–142.

Sarah B. Johnson, Manuel F. Casanova. Interhemispheric connectivity: the evolution and nature of the corpus callosum. In: Timothy B. Westland, Robert N. Calton, eds. Handbook on white matter: structure, function, and changes, 3–15. Hauppauge: Nova Science Publishers; 2009 Jul 28.

Manuel F. Casanova, Ayman El-Baz, Meghan Mott, Glenn Mannheim, Hossam Hassan, Rachid Fahmi, Jay Giedd, Judith M. Rumsey, Andrew E. Switala, Aly Farag. Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy. Journal of Autism and Developmental Disorders 2009 May; 39(5): 751–764.

Manuel Casanova, Juan Trippe. Radial cytoarchitecture and patterns of cortical connectivity in autism. Philosophical Transactions of the Royal Society, B. Biological Sciences 2009 May 27; 364(1522): 1433–1436.

Ratnam S. Seelan, Jaganathan Lakshmanan, Manuel F. Casanova, Ranga N. Parthasarathy. Identification of myo-inositol-3-phosphate synthase isoforms: characterization, expression and putative role of a 16 kDa γc isoform. Journal of Biological Chemistry 2009 Apr 3; 284(14): 9443–9457.

Estate M. Sokhadze, Ayman El-Baz, Joshua Baruth, Grace Mathai, Lonnie Sears, Manuel F. Casanova. Effects of low frequency repetitive transcranial magnetic stimulation (rTMS) on gamma frequency oscillations and event-related potentials during processing of illusory figures in autism. Journal of Autism and Developmental Disorders 2009 April; 39(4): 619–634.

Valid XHTML 1.1

Contact persons for this Web site are Manuel F. Casanova (principal investigator) and Andrew E. Switala (administrator).